Seroepidemiology of enterovirus A71 infection in prospective cohort studies of children in southern China, 2013-2018
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Published:2022-11-26
Issue:1
Volume:13
Page:
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ISSN:2041-1723
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Container-title:Nature Communications
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language:en
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Short-container-title:Nat Commun
Author:
Yang JuanORCID, Liao Qiaohong, Luo Kaiwei, Liu Fengfeng, Zhou YonghongORCID, Zou Gang, Huang Wei, Yu Shuanbao, Wei Xianglin, Zhou Jiaxin, Dai Bingbing, Qiu Qi, Altmeyer Ralf, Hu Hongan, Paireau JulietteORCID, Luo Li, Gao Lidong, Nikolay Birgit, Hu Shixiong, Xing Weijia, Wu Peng, van Doorn H. Rogier, Horby Peter W.ORCID, Simmonds Peter, Leung Gabriel M.ORCID, Cowling Benjamin J., Cauchemez SimonORCID, Yu HongjieORCID
Abstract
AbstractEnterovirus A71 (EV-A71)–related hand, foot, and mouth disease (HFMD) imposes a substantial clinical burden in the Asia Pacific region. To inform policy on the introduction of the EV-A71 vaccine into the National Immunization Programme, we investigated the seroepidemiological characteristics of EV-A71 in two prospective cohorts of children in southern China conducted between 2013 and 2018. Our results show that maternal antibody titres declined rapidly in neonates, with over half becoming susceptible to EV-A71 at 1 month of age. Between 6 months and 2 years of age, over 80% of study participants were susceptible, while one third remained susceptible at 5 years old. The highest incidence of EV-A71 infections was observed in children aged 5-6 months. Our findings support EV-A71 vaccination before 6 months for birth cohorts in southern China, potentially with a one-time catch-up vaccination for children 6 months-5 years old. More regionally representative longitudinal seroepidemiological studies are needed to further validate these findings.
Publisher
Springer Science and Business Media LLC
Subject
General Physics and Astronomy,General Biochemistry, Genetics and Molecular Biology,General Chemistry,Multidisciplinary
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