Wireless, battery-free, multifunctional integrated bioelectronics for respiratory pathogens monitoring and severity evaluation
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Published:2023-11-20
Issue:1
Volume:14
Page:
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ISSN:2041-1723
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Container-title:Nature Communications
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language:en
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Short-container-title:Nat Commun
Author:
Li Hu, Gong Huarui, Wong Tsz Hung, Zhou JingkunORCID, Wang Yuqiong, Lin Long, Dou Ying, Jia HuilingORCID, Huang XingcanORCID, Gao Zhan, Shi Rui, Huang YaORCID, Chen Zhenlin, PARK WooyoungORCID, Li Ji Yu, Chu Hongwei, Jia ShengxinORCID, Wu Han, Wu MenggeORCID, Liu YimingORCID, Li DengfengORCID, Li JianORCID, Xu Guoqiang, Chang Tianrui, Zhang Binbin, Gao Yuyu, Su Jingyou, Bai Hao, Hu Jie, Yiu Chun Ki, Xu ChenjieORCID, Hu WenchuangORCID, Huang JiandongORCID, Chang Lingqian, Yu XingeORCID
Abstract
AbstractThe rapid diagnosis of respiratory virus infection through breath and blow remains challenging. Here we develop a wireless, battery-free, multifunctional pathogenic infection diagnosis system (PIDS) for diagnosing SARS-CoV-2 infection and symptom severity by blow and breath within 110 s and 350 s, respectively. The accuracies reach to 100% and 92% for evaluating the infection and symptom severity of 42 participants, respectively. PIDS realizes simultaneous gaseous sample collection, biomarker identification, abnormal physical signs recording and machine learning analysis. We transform PIDS into other miniaturized wearable or portable electronic platforms that may widen the diagnostic modes at home, outdoors and public places. Collectively, we demonstrate a general-purpose technology for rapidly diagnosing respiratory pathogenic infection by breath and blow, alleviating the technical bottleneck of saliva and nasopharyngeal secretions. PIDS may serve as a complementary diagnostic tool for other point-of-care techniques and guide the symptomatic treatment of viral infections.
Publisher
Springer Science and Business Media LLC
Subject
General Physics and Astronomy,General Biochemistry, Genetics and Molecular Biology,General Chemistry,Multidisciplinary
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