Origami-inspired soft fluidic actuation for minimally invasive large-area electrocorticography

Author:

Coles LawrenceORCID,Ventrella DomenicoORCID,Carnicer-Lombarte AlejandroORCID,Elmi Alberto,Troughton Joe G.ORCID,Mariello MassimoORCID,El Hadwe Salim,Woodington Ben J.,Bacci Maria L.ORCID,Malliaras George G.ORCID,Barone Damiano G.ORCID,Proctor Christopher M.ORCID

Abstract

AbstractElectrocorticography is an established neural interfacing technique wherein an array of electrodes enables large-area recording from the cortical surface. Electrocorticography is commonly used for seizure mapping however the implantation of large-area electrocorticography arrays is a highly invasive procedure, requiring a craniotomy larger than the implant area to place the device. In this work, flexible thin-film electrode arrays are combined with concepts from soft robotics, to realize a large-area electrocorticography device that can change shape via integrated fluidic actuators. We show that the 32-electrode device can be packaged using origami-inspired folding into a compressed state and implanted through a small burr-hole craniotomy, then expanded on the surface of the brain for large-area cortical coverage. The implantation, expansion, and recording functionality of the device is confirmed in-vitro and in porcine in-vivo models. The integration of shape actuation into neural implants provides a clinically viable pathway to realize large-area neural interfaces via minimally invasive surgical techniques.

Funder

RCUK | Biotechnology and Biological Sciences Research Council

RCUK | Engineering and Physical Sciences Research Council

DH | NIHR | Invention for Innovation

Publisher

Springer Science and Business Media LLC

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