Features of acute COVID-19 associated with post-acute sequelae of SARS-CoV-2 phenotypes: results from the IMPACC study
-
Published:2024-01-03
Issue:1
Volume:15
Page:
-
ISSN:2041-1723
-
Container-title:Nature Communications
-
language:en
-
Short-container-title:Nat Commun
Author:
Ozonoff AlORCID, Jayavelu Naresh Doni, Liu Shanshan, Melamed Esther, Milliren Carly E., Qi Jingjing, Geng Linda N., McComsey Grace A., Cairns Charles B.ORCID, Baden Lindsey R., Schaenman Joanna, Shaw Albert C., Samaha HadyORCID, Seyfert-Margolis Vicki, Krammer FlorianORCID, Rosen Lindsey B., Steen HannoORCID, Syphurs Caitlin, Dandekar Ravi, Shannon Casey P.ORCID, Sekaly Rafick P.ORCID, Ehrlich Lauren I. R.ORCID, Corry David B., Kheradmand FarrahORCID, Atkinson Mark A., Brakenridge Scott C., Higuita Nelson I. Agudelo, Metcalf Jordan P., Hough Catherine L., Messer William B.ORCID, Pulendran BaliORCID, Nadeau Kari C.ORCID, Davis Mark M.ORCID, Sesma Ana FernandezORCID, Simon VivianaORCID, van Bakel HarmORCID, Kim-Schulze Seunghee, Hafler David A.ORCID, Levy OferORCID, Kraft Monica, Bime Chris, Haddad Elias K.ORCID, Calfee Carolyn S., Erle David J.ORCID, Langelier Charles R.ORCID, Eckalbar Walter, Bosinger Steven E.ORCID, McEnaney Kerry, Barton Brenda, Lentucci Claudia, Saluvan Mehmet, Chang Ana C., Hoch Annmarie, Albert Marisa, Shaheen Tanzia, Kho Alvin T., Thomas Sanya, Chen Jing, Murphy Maimouna D., Cooney Mitchell, Hayati Arash Nemati, Bryant Robert, Abraham James, Presnell Scott, Jancsyk Tomasz, Maguire Cole, Lee Brian, Fourati Slim, Esserman Denise A., Guan Leying, Gygi Jeremy, Pawar Shrikant, Brito Anderson, Fragiadakis Gabriela K., Patel Ravi, Tebbutt Scott J., Overton James A., Vita Randi, Westendorf Kerstin, Thyagarajan Rama V., Rousseau Justin F., Wylie Dennis, Triplett Todd A., Kojic Erna, Chinthrajah Sharon, Ahuja Neera, Rogers Angela J., Artandi Maja, Yendewa George, Powell Debra L., Kim James N., Simmons Brent, Goonewardene I. Michael, Smith Cecilia M., Martens Mark, Sherman Amy C., Walsh Stephen R., Issa Nicolas C., Salehi-Rad Ramin, Dela Cruz Charles, Farhadian Shelli, Iwasaki Akiko, Ko Albert I., Anderson Evan J., Mehta Aneesh K., Sevransky Jonathan E., Leligdowicz Aleksandra, Matthay Michael A., Singer Jonathan P., Kangelaris Kirsten N., Hendrickson Carolyn M., Krummel Matthew F., Woodruff Prescott G., Anderson Matthew L., Guirgis Faheem W., Drevets Douglas A., Brown Brent R., Siegel Sarah A. R., Lu Zhengchun, Mosier Jarrod, Kimura Hiroki, Khor Bernard, Rahman Adeeb, Stadlbauer Daniel, Dutta Jayeeta, Gonzalez-Reiche Ana Silvia, van de Guchte Adriana, Carreño Juan Manuel, Singh Gagandeep, Raskin Ariel, Tcheou Johnstone, Bielak Dominika, Kawabata Hisaaki, Xie Hui, Kelly Geoffrey, Patel Manishkumar, Nie Kai, Yellin Temima, Fried Miriam, Sullivan Leeba, Morris Sara, Sieg Scott, van Zalm Patrick, Fatou Benoit, Mendez Kevin, Lasky-Su Jessica, Hutton Scott R., Michelotti Greg, Wong Kari, Jha Meenakshi, Viode Arthur, Kanarek Naama, Petrova Boryana, Zhao Yujiao, Boddapati Arun K., Tharp Greg K., Pellegrini Kathryn L., Beagle Elizabeth, Cowan David, Hamilton Sydney, Ribeiro Susan Pereira, Hodder Thomas, Lee Serena, Wilson Michael R., Alvarenga Bonny, Rajan Jayant, Schroeder Andrew W., Tsitsiklis Alexandra, Mick Eran, Guerrero Yanedth Sanchez, Love Christina, Maliskova Lenka, Adkisson Michael, Siles Nadia, Geltman Janelle, Hurley Kerin, Saksena Miti, Altman Deena, Srivastava Komal, Eaker Lily Q., Bermúdez-González Maria C., Beach Katherine F., Sominsky Levy A., Azad Arman R., Mulder Lubbertus C. F., Kleiner Giulio, Lee Alexandra S., Do Evan, Fernandes Andrea, Manohar Monali, Hagan Thomas, Blish Catherine A., Din Hena Naz, Roque Jonasel, Yang Samuel, Sigal Natalia, Chang Iris, Tribout Heather, Harris Paul, Consolo Mary, Connors Jennifer, Bernui Mariana, Kutzler Michele A., Edwards Carolyn, Lee Edward, Lin Edward, Croen Brett, Semenza Nicholas C., Rogowski Brandon, Melnyk Nataliya, Woloszczuk Kyra, Cusimano Gina, Bell Mathew R., Furukawa Sara, McLin Renee, Schearer Pamela, Sheidy Julie, Tegos George P., Nagle Crystal, Smolen Kinga, Desjardins Michael, van Haren Simon, Mitre Xhoi, Cauley Jessica, Li Xiaofang, Tong Alexandra, Evans Bethany, Montesano Christina, Licona Jose Humberto, Krauss Jonathan, Chang Jun Bai Park, Izaguirre Natalie, Rooks Rebecca, Elashoff David, Brook Jenny, Ramires-Sanchez Estefania, Llamas Megan, Rivera Adreanne, Perdomo Claudia, Ward Dawn C., Magyar Clara E., Fulcher Jennifer A., Pickering Harry C., Sen Subha, Chaudhary Omkar, Coppi Andreas, Fournier John, Mohanty Subhasis, Muenker M. Catherine, Nelson Allison, Raddassi Khadir, Rainone Michael, Ruff William E., Salahuddin Syim, Schulz Wade L., Vijayakumar Pavithra, Wang Haowei, Wunder Elsio, Young H. Patrick, Rothman Jessica, Konstorum Anna, Chen Ernie, Cotsapas Chris, Grubaugh Nathan D., Wang Xiaomei, Xu Leqi, Asashima Hiromitsu, Bristow Laurel, Hussaini Laila, Hellmeister Kieffer, Wimalasena Sonia Tandon, Cheng Andrew, Spainhour Christine, Scherer Erin M., Johnson Brandi, Bechnak Amer, Ciric Caroline R., Hewitt Lauren, Carter Erin, Mcnair Nina, Panganiban Bernadine, Huerta Christopher, Usher Jacob, Vaysman Tatyana, Holland Steven M., Abe-Jones Yumiko, Asthana Saurabh, Beagle Alexander, Bhide Sharvari, Carrillo Sidney A., Chak Suzanna, Ghale Rajani, Gonzalez Ana, Jauregui Alejandra, Jones Norman, Lea Tasha, Lee Deanna, Lota Raphael, Milush Jeff, Nguyen Viet, Pierce Logan, Prasad Priya A., Rao Arjun, Samad Bushra, Shaw Cole, Sigman Austin, Sinha Pratik, Ward Alyssa, Willmore Andrew, Zhan Jenny, Rashid Sadeed, Rodriguez Nicklaus, Tang Kevin, Altamirano Luz Torres, Betancourt Legna, Curiel Cindy, Sutter Nicole, Paz Maria Tercero, Tietje-Ulrich Gayelan, Leroux Carolyn, Thakur Neeta, Vasquez Joshua J., Santhosh Lekshmi, Song Li-Zhen, Nelson Ebony, Moldawer Lyle L., Borresen Brittany, Roth-Manning Brittney, Ungaro Ricardo F., Oberhaus Jordan, Booth J. Leland, Sinko Lauren A., Brunton Amanda, Sullivan Peter E., Strnad Matthew, Lyski Zoe L., Coulter Felicity J., Micheleti Courtney, Conway Michelle, Francisco Dave, Molzahn Allyson, Erickson Heidi, Wilson Connie Cathleen, Schunk Ron, Sierra Bianca, Hughes Trina, Peters BjoernORCID, Kleinstein Steven H.ORCID, Reed Elaine F., Augustine Alison D., Diray-Arce Joann, Maecker Holden T.ORCID, Altman Matthew C.ORCID, Montgomery Ruth R.ORCID, Becker Patrice M.ORCID, Rouphael NadineORCID, , , , , , ,
Abstract
AbstractPost-acute sequelae of SARS-CoV-2 (PASC) is a significant public health concern. We describe Patient Reported Outcomes (PROs) on 590 participants prospectively assessed from hospital admission for COVID-19 through one year after discharge. Modeling identified 4 PRO clusters based on reported deficits (minimal, physical, mental/cognitive, and multidomain), supporting heterogenous clinical presentations in PASC, with sub-phenotypes associated with female sex and distinctive comorbidities. During the acute phase of disease, a higher respiratory SARS-CoV-2 viral burden and lower Receptor Binding Domain and Spike antibody titers were associated with both the physical predominant and the multidomain deficit clusters. A lower frequency of circulating B lymphocytes by mass cytometry (CyTOF) was observed in the multidomain deficit cluster. Circulating fibroblast growth factor 21 (FGF21) was significantly elevated in the mental/cognitive predominant and the multidomain clusters. Future efforts to link PASC to acute anti-viral host responses may help to better target treatment and prevention of PASC.
Funder
U.S. Department of Health & Human Services | National Institutes of Health
Publisher
Springer Science and Business Media LLC
Subject
General Physics and Astronomy,General Biochemistry, Genetics and Molecular Biology,General Chemistry,Multidisciplinary
Reference74 articles.
1. COVID-19 rapid guideline: managing the long-term effects of COVID-19. https://www.nice.org.uk/guidance/ng188. (2022). 2. National Institute for Health and Care Excellence: Clinical Guidelines. COVID-19 rapid guideline: managing the long-term effects of COVID-19. London: National Institute for Health and Care Excellence (NICE) Copyright © NICE 2020. (2020). 3. Admon, A. J. et al. Assessment of symptom, disability, and financial trajectories in patients hospitalized for COVID-19 at 6 months. JAMA Netw. Open 6, e2255795 (2023). 4. Groff, D. et al. Short-term and long-term rates of postacute sequelae of SARS-CoV-2 infection: a systematic review. JAMA Netw. Open 4, e2128568 (2021). 5. Merad, M., Blish, C. A., Sallusto, F. & Iwasaki, A. The immunology and immunopathology of COVID-19. Science 375, 1122–1127 (2022).
|
|