Are vitamin and mineral deficiencies a major cancer risk?
Author:
Publisher
Springer Science and Business Media LLC
Subject
General Earth and Planetary Sciences,General Environmental Science
Link
http://www.nature.com/articles/nrc886.pdf
Reference146 articles.
1. Doll, R. & Peto, R. The Causes of Cancer (University Press, Oxford, 1981). (Reference deleted in proof.)This classical paper discusses the risk of cancer and the link to lifestyle factors.
2. Hagen, T. M. et al. Feeding acetyl-L-carnitine and lipoic acid to old rats significantly improves metabolic function while decreasing oxidative stress. Proc. Natl Acad. Sci. USA 99, 1870–1875 (2002).
3. Liu, J. et al. Memory loss in old rats is associated with brain mitochondrial decay and RNA/DNA oxidation: partial reversal by feeding acetyl-L-carnitine and/or R-alpha-lipoic acid. Proc. Natl Acad. Sci. USA 99, 2356–2361 (2002).
4. Liu, J., Killilea, D. & Ames, B. N. Age-associated mitochondrial oxidative decay: improvement of carnitine acetyltransferase substrate-binding affinity and activity in brain by feeding old rats acetyl-L-carnitine and/or R-alpha-lipoic acid. Proc. Natl Acad. Sci. USA 99, 1876–1881 (2002).
5. Ames, B. N., Elson-Schwab, I. & Silver, E. A. High-dose vitamin therapy stimulates variant enzymes with decreased coenzyme binding affinity (increased Km): relevance to genetic disease and polymorphisms. Am. J. Clin. Nutr. 75, 616–658 (2002).
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