HCV derived from sera of HCV-infected patients induces pro-fibrotic effects in human primary fibroblasts by activating GLI2-Reference-Cited by-同舟云学术

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HCV derived from sera of HCV-infected patients induces pro-fibrotic effects in human primary fibroblasts by activating GLI2

Published:2016-08 Issue:1 Volume:6 Page:
ISSN:2045-2322
Container-title:Scientific Reports
language:en
Short-container-title:Sci Rep

Author:

Granato M.,Zompetta C.,Vescarelli E.,Rizzello C.,Cardi A.,Valia S.,Antonelli G.,Marchese C.,Torrisi M. R.,Faggioni A.,Cirone M.

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

Link

http://www.nature.com/articles/srep30649.pdf

Reference52 articles.

1. Bosselut, N. et al. Distinct proteomic features of two fibrogenic liver cell populations: hepatic stellate cells and portal myofibroblasts. Proteomics 10, 1017–1028, doi: 10.1002/pmic.200900257 (2010).

2. Chang, K. S. et al. Replication of hepatitis C virus (HCV) RNA in mouse embryonic fibroblasts: protein kinase R (PKR)-dependent and PKR-independent mechanisms for controlling HCV RNA replication and mediating interferon activities. Journal of virology 80, 7364–7374, doi: 10.1128/JVI.00586-06 (2006).

3. Watanabe, N. et al. Hepatitis C virus RNA replication in human stellate cells regulates gene expression of extracellular matrix-related molecules. Biochemical and biophysical research communications 407, 135–140, doi: 10.1016/j.bbrc.2011.02.125 (2011).

4. Aoudjehane, L. et al. Infection of Human Liver Myofibroblasts by Hepatitis C Virus: A Direct Mechanism of Liver Fibrosis in Hepatitis C. PloS one 10, e0134141, doi: 10.1371/journal.pone.0134141 (2015).

5. Ingham, P. W. & McMahon, A. P. Hedgehog signaling in animal development: paradigms and principles. Genes & development 15, 3059–3087, doi: 10.1101/gad.938601 (2001).

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