Intraoperative margin assessment for basal cell carcinoma with deep learning and histologic tumor mapping to surgical site

Author:

Levy Joshua JORCID,Davis Matthew J,Chacko Rachael S,Davis Michael J,Fu Lucy J,Goel Tarushii,Pamal AkashORCID,Nafi IrfanORCID,Angirekula Abhinav,Suvarna Anish,Vempati Ram,Christensen Brock CORCID,Hayden Matthew S,Vaickus Louis J,LeBoeuf Matthew R

Abstract

AbstractSuccessful treatment of solid cancers relies on complete surgical excision of the tumor either for definitive treatment or before adjuvant therapy. Intraoperative and postoperative radial sectioning, the most common form of margin assessment, can lead to incomplete excision and increase the risk of recurrence and repeat procedures. Mohs Micrographic Surgery is associated with complete removal of basal cell and squamous cell carcinoma through real-time margin assessment of 100% of the peripheral and deep margins. Real-time assessment in many tumor types is constrained by tissue size, complexity, and specimen processing / assessment time during general anesthesia. We developed an artificial intelligence platform to reduce the tissue preprocessing and histological assessment time through automated grossing recommendations, mapping and orientation of tumor to the surgical specimen. Using basal cell carcinoma as a model system, results demonstrate that this approach can address surgical laboratory efficiency bottlenecks for rapid and complete intraoperative margin assessment.

Funder

U.S. Department of Health & Human Services | National Institutes of Health

Publisher

Springer Science and Business Media LLC

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