Gut CD4+ T cell phenotypes are a continuum molded by microbes, not by TH archetypes
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Published:2021-01-18
Issue:2
Volume:22
Page:216-228
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ISSN:1529-2908
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Container-title:Nature Immunology
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language:en
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Short-container-title:Nat Immunol
Author:
Kiner Evgeny, Willie Elijah, Vijaykumar Brinda, Chowdhary Kaitavjeet, Schmutz Hugo, Chandler Jodie, Schnell Alexandra, Thakore Pratiksha I., LeGros Graham, Mostafavi Sara, Mathis DianeORCID, Benoist ChristopheORCID, Aguilar Oscar, Allan Rhys, Astarita Jilian, Austen K. Frank, Barrett Nora, Baysoy Alev, Benoist Christophe, Brown Brian D., Buechler Matthew, Buenrostro Jason, Casanova Maria Acebes, Choi Kyunghee, Chowdhary Kaitavjeet, Colonna Marco, Crowl Ty, Deng Tianda, Desai Jigar V., Desland Fiona, Dhainaut Maxime, Ding Jiarui, Dominguez Claudia, Dwyer Daniel, Frascoli Michela, Gal-Oz Shani, Goldrath Ananda, Grieshaber-Bouyer Ricardo, Jia Baosen, Johanson Tim, Jordan Stefan, Kang Joonsoo, Kapoor Varun, Kenigsberg Ephraim, Kim Joel, wook Kim Ki, Kiner Evgeny, Kronenberg Mitchell, Lanier Lewis, Laplace Catherine, Lareau Caleb, Leader Andrew, Lee Jisu, Magen Assaf, Maier Barbara, Maslova Alexandra, Mathis Diane, McFarland Adelle, Merad Miriam, Meunier Etienne, Monach Paul, Mostafavi Sara, Muller Soren, Muus Christoph, Ner-Gaon Hadas, Nguyen Quyhn, Nigrovic Peter A., Novakovsky German, Nutt Stephen, Omilusik Kayla, Ortiz-Lopez Adriana, Paynich Mallory, Peng Vincent, Potempa Marc, Pradhan Rachana, Quon Sara, Ramirez Ricardo, Ramanan Deepshika, Randolph Gwendalyn, Regev Aviv, Rose Samuel A., Seddu Kumba, Shay Tal, Shemesh Avishai, Shyer Justin, Smilie Christopher, Spidale Nick, Subramanian Ayshwarya, Sylvia Katelyn, Tellier Julie, Turley Shannon, Vijaykumar Brinda, Wagers Amy, Wang Chendi, Wang Peter L., Wroblewska Aleksandra, Yang Liang, Yim Aldrin, Yoshida Hideyuki,
Funder
Division of Intramural Research, National Institute of Allergy and Infectious Diseases Boehringer Ingelheim Fonds U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences Harvard University | Harvard Stem Cell Institute
Publisher
Springer Science and Business Media LLC
Subject
Immunology,Immunology and Allergy
Reference65 articles.
1. Araneo, B. A., Marrack, P. C. & Kappler, J. W. Functional heterogeneity among the T-derived lymphocytes of the mouse. II. Sensitivity of subpopulations to anti-thymocyte serum. J. Immunol. 114, 747–751 (1975). 2. Bottomly, K. A functional dichotomy in CD4+ T lymphocytes. Immunol. Today 9, 268–274 (1988). 3. Mosmann, T. R. et al. Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J. Immunol. 136, 2348–2357 (1986). 4. Killar, L. et al. Cloned, Ia-restricted T cells that do not produce interleukin 4 (IL-4)/B cell stimulatory factor 1 (BSF-1) fail to help antigen-specific B cells. J. Immunol. 138, 1674–1679 (1987). 5. Korn, T., Bettelli, E., Oukka, M. & Kuchroo, V. K. IL-17 and TH17 cells. Annu. Rev. Immunol. 27, 485–517 (2009).
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