Is the anti-aging effect of ACE2 due to its role in the renin-angiotensin system?—Findings from a comparison of the aging phenotypes of ACE2-deficient, Tsukuba hypertensive, and Mas-deficient mice

Is the anti-aging effect of ACE2 due to its role in the renin-angiotensin system?—Findings from a comparison of the aging phenotypes of ACE2-deficient, Tsukuba hypertensive, and Mas-deficient mice—

Published:2023-02-14 Issue:5 Volume:46 Page:1210-1220
ISSN:0916-9636
Container-title:Hypertension Research
language:en
Short-container-title:Hypertens Res

Author:

Takeshita Hikari,Yamamoto Koichi,Mogi Masaki,Nozato Satoko,Rakugi Hiromi

Publisher

Springer Science and Business Media LLC

Link

https://www.nature.com/articles/s41440-023-01189-y.pdf

Reference86 articles.

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3. Oliverio MI, Kim HS, Ito M, Le T, Audoly L, Best CF, et al. Reduced growth, abnormal kidney structure, and type 2 (AT2) angiotensin receptor-mediated blood pressure regulation in mice lacking both AT1A and AT1B receptors for angiotensin II. Proc Natl Acad Sci USA. 1998;95:15496–501.

4. Kim S, Iwao H. Molecular and cellular mechanisms of angiotensin II-mediated cardiovascular and renal diseases. Pharm Rev. 2000;52:11–34.

5. Griendling KK, Lassègue B, Alexander RW. Angiotensin receptors and their therapeutic implications. Annu Rev Pharm Toxicol. 1996;36:281–306.

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