Synergy of therapeutic heterologous prime-boost hepatitis B vaccination with CpG-application to improve immune control of persistent HBV infection
Author:
Funder
Deutsches Zentrum für Infektionsforschung
Deutsche Forschungsgemeinschaft
Publisher
Springer Science and Business Media LLC
Subject
Multidisciplinary
Link
http://www.nature.com/articles/s41598-019-47149-w.pdf
Reference32 articles.
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2. Rehermann, B. & Nascimbeni, M. Immunology of hepatitis B virus and hepatitis C virus infection. Nat Rev Immunol 5, 215–229 (2005).
3. Knolle, P. A. & Thimme, R. Hepatic immune regulation and its involvement in viral hepatitis infection. Gastroenterology 146, 1193–1207, https://doi.org/10.1053/j.gastro.2013.12.036 (2014).
4. Lok, A. S. et al. Antiviral therapy for chronic hepatitis B viral infection in adults: A systematic review and meta-analysis. Hepatology 63, 284–306, https://doi.org/10.1002/hep.28280 (2016).
5. Liaw, Y. F., Sheen, I. S., Chen, T. J., Chu, C. M. & Pao, C. C. Incidence, determinants and significance of delayed clearance of serum HBsAg in chronic hepatitis B virus infection: a prospective study. Hepatology 13, 627–631 (1991).
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