Improving the accuracy and robustness of carotid-femoral pulse wave velocity measurement using a simplified tube-load model

Author:

Xu Lisheng,Zhou Shuran,Wang Lu,Yao Yang,Hao Liling,Qi Lin,Yao Yudong,Han Hongguang,Mukkamala Ramakrishna,Greenwald Stephen E.

Abstract

AbstractArterial stiffness, as measured by pulse wave velocity, for the early non-invasive screening of cardiovascular disease is becoming ever more widely used and is an independent prognostic indicator for a variety of pathologies including arteriosclerosis. Carotid-femoral pulse wave velocity (cfPWV) is regarded as the gold standard for aortic stiffness. Existing algorithms for cfPWV estimation have been shown to have good repeatability and accuracy, however, further assessment is needed, especially when signal quality is compromised. We propose a method for calculating cfPWV based on a simplified tube-load model, which allows for the propagation and reflection of the pulse wave. In-vivo cfPWV measurements from 57 subjects and numerical cfPWV data based on a one-dimensional model were used to assess the method and its performance was compared to three other existing approaches (waveform matching, intersecting tangent, and cross-correlation). The cfPWV calculated using the simplified tube-load model had better repeatability than the other methods (Intra-group Correlation Coefficient, ICC = 0.985). The model was also more accurate than other methods (deviation, 0.13 ms−1) and was more robust when dealing with noisy signals. We conclude that the determination of cfPWV based on the proposed model can accurately and robustly evaluate arterial stiffness.

Funder

National Key Research and Development Program of China

National Natural Science Foundation of China

Fundamental Research Funds for the Central Universities

Shenyang Science and Technology Plan Fund

Member Program of Neusoft Research of Intelligent Healthcare Technology, Co. Ltd.

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

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