NPLOC4 is a potential target and a poor prognostic signature in lung squamous cell carcinoma

Author:

Wang Naixue,Zhu Dantong,Liu Yao,Wu Jingran,Wang Meiling,Jin Shanxiu,Fu Fangwei,Li Baolei,Ji Hongjuan,Du Cheng,Zheng Zhendong

Abstract

AbstractFew prognostic biomarkers exist for lung squamous cell carcinoma (LUSC), which has a poor five-year survival rate. Using bioinformatics, this study evaluated NPLOC4 as a prognostic marker for patients with lung squamous cell carcinoma. Shorter survival periods and tumor growth were linked to high NPLOC4 expression.Disulfiram (DSF) combined with copper (Cu) targets NPLOC4 to achieve antitumor effects in lung squamous cell carcinoma. Thus, we investigated the effects of DSF with Cu in LUSC. Gene-set enrichment analysis identified ubiquitin-mediated proteolysis as the NPLOC4-associated mechanism influencing LUSC prognosis. In SK-MES-1 cell lines, DSF + Cu increased K48-linked ubiquitinated protein expression and apoptosis. This study identified NPLOC4 as a prognostic biomarker and a potential therapeutic target for LUSC.

Funder

Shenyang Science and Technology Bureau

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

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