Author:
He Xianghua,Yang Jian,Feng Jiaming,Huang Hongyan,Dong Xiaolin,Zhao Quanzhen,Shen Qiuyan,Hu Caiyou,Xu Yanming
Abstract
AbstractThis study aimed to investigate the relationship between venous blood parameters and respiratory functions in patients with amyotrophic lateral sclerosis (ALS) and develop a model to predict respiratory impairment for individual patients with ALS. A total of 416 ALS patients were included in the study, and various hematologic and biochemical laboratory parameters as well as demographic and clinical factors were collected and compared. A multivariable logistic regression model was constructed to assess the association between FVC and venous blood biomarkers and clinical factors. The results showed that along with onset age, bulbar-onset, disease duration, BMI, eosinophil count (EO#), basophil count (BASO#), creatinine (CREA), uric acid (URCI) and low-density lipoprotein cholesterol/high-density lipoprotein cholesterol (LDL/HDL) ratio were associated with reduced FVC. The area under the ROC curve is 0.735 for the test set and 0.721 for the validation set. The study also developed a relatively acceptable model for predicting respiratory impairment in ALS patients. These findings suggest that EO#, BASO#, CREA, URIC and LDL/HDL ratio can be useful in assessing FVC in ALS and can be easily accessible, accurate, and low-cost parameters.
Funder
National Natural Science Foundation of China
National Key Research and Development Program of China
Miaozi Project in Science and Technology Innovation Program of Sichuan Province
Basic Conditions Platform Construction Project of Sichuan Science and Technology Department
1.3.5 Project for disciplines of excellence, West China Hospital, Sichuan University
Publisher
Springer Science and Business Media LLC