Author:
Morioka Masakazu,Takamura Yoshihiro,Nagai Kazuki,Yoshida Shigeo,Mori Junya,Takeuchi Masaru,Sawada Tomoko,Sone Kumiko,Fukuyama Hisashi,Kusuhara Sentaro,Yasukawa Tsutomu,Murakami Tomoya,Tabuchi Hitoshi,Nagasato Daisuke,Hirano Takao,Ueda Tetsuo,Jujo Tatsuya,Sasajima Hirofumi,Mitamura Yoshinori,Ishikawa Kunihiro,Inatani Masaru
Abstract
AbstractIntravitreal injection (IVI) of anti-vascular endothelial growth factor (VEGF) is the standard treatment modality in various types of retinal diseases. However, endophthalmitis remains the most serious complication. Despite the lack of evidence that antibiotics prevent endophthalmitis, topical antibiotics are still used routinely in Japan. We conducted a retrospective multicenter study by analyzing records from patients who underwent IVI of anti-VEGF agents with or without antibiotic treatment. In the analysis of a total of 147,440 eyes, the incidence of endophthalmitis was 0.007%: 0.005% with no use of antibiotics, 0.009% with antibiotic pretreatment, 0.012% with posttreatment, and 0.005% with pre- and posttreatment. There was no statistically significant difference among the four groups (chi-square test,p = 0.57). Most facilities used masks, sterilized gloves, and drapes. Nine of the 10 eyes that developed endophthalmitis received topical antibiotics, and all infected eyes underwent IVI with aflibercept, not the prefilled syringe delivery system. In four patients who received multiple IVI, the detection of causative bacteria revealed resistance to used antibiotics. Data from this large population, treated with or without antibiotics, suggests that antibiotic prophylaxis does not reduce the rate of endophthalmitis after IVI.
Publisher
Springer Science and Business Media LLC
Cited by
9 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献