Author:
Hirakawa Toyofumi,Yotsumoto Fusanori,Shirasu Naoto,Kiyoshima Chihiro,Urushiyama Daichi,Yoshikawa Kenichi,Miyata Kohei,Kurakazu Masamitsu,Koga Kaori Azuma,Aoki Mikiko,Nabeshima Kazuki,Koga Kaori S.,Osuga Yutaka,Komatsu Hiroaki,Taniguchi Fuminori,Harada Tasuku,Yasunaga Shin’ichiro,Miyamoto Shingo
Abstract
AbstractEndometriosis, which exhibits enigmatic pathological features such as stromal fibrosis and proliferation of ectopic epithelial cells, is known as a refractory disease. Mesenchymal stem cells modulate the fibrosis in stromal tissues through their trophic and immunomodulatory properties. To investigate the potential of stem cells in treating endometriosis, we examined the secondary morphology and molecular alterations in endometriosis-like lesions after the administration of adipose tissue-derived stem cells (ASCs) to an experimental murine model of endometriosis. The infused ASCs were found integrated in the endometriosis-like lesions. Accompanied by the suppression of stromal fibrosis and proliferation of endometriotic epithelial cells, the infusion of ASCs with stemness potential (early passage of ASCs) suppressed the growth of endometriosis-like lesions and inhibited the expression of pro-inflammatory and pro-fibrotic cytokines, whereas no significant attenuation of endometriosis-like lesions occurred after the infusion of ASCs without stemness potential (late passage of ASCs). Accordingly, the trophic and immunomodulatory properties of ASCs may regulate fibrosis in endometriosis-like lesions, suggesting that regenerative medicine could be recognized as an innovative treatment for patients with endometriosis through the accumulation of evidence of preclinical efficacy.
Funder
A Grant-in-Aid from the Kakihara Science and Technology Foundation
JSPS KAKENHI
The Central Research Institute of Fukuoka University
A Grant-in-Aid from the Society for Women's Health Science Research
Publisher
Springer Science and Business Media LLC
Cited by
3 articles.
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