Author:
Salim Mohamed M.,Radwan Aya saad,Hadad Ghada M.,Belal Fathalla,Elkhoudary Mahmoud M.
Abstract
AbstractTelmisartan (TEL) and Nebivolol (NEB) are frequently co-formulated in a single dosage form that is frequently prescribed for the treatment of hypertension, moreover, telmisartan is currently proposed to be used to treat COVID19-induced lung inflammation. Green rapid, simple, and sensitive synchronous spectrofluorimetric techniques for simultaneous estimation of TEL and NEB in their co-formulated pharmaceutical preparations and human plasma were developed and validated. Synchronous fluorescence intensity at 335 nm was used for TEL determination (Method I). For the mixture, the first derivative synchronous peak amplitudes (D1) at 296.3 and 320.5 nm were used for simultaneous estimation of NEB and TEL, respectively (Method II). The calibration plots were rectilinear over the concentration ranges of 30–550 ng/mL, and 50–800 ng/mL for NEB and TEL, respectively. The high sensitivity of the developed methods allowed for their analysis in human plasma samples. NEB`s Quantum yield was estimated by applying the single-point method. The greenness of the proposed approaches was evaluated using the Eco-scale, National Environmental Method Index (NEMI), and Green Analytical Procedure Index (GAPI) methods.
Publisher
Springer Science and Business Media LLC
Reference49 articles.
1. Yuki, K., Fujiogi, M. & Koutsogiannaki, S. COVID-19 pathophysiology: A review. Clin. Immunol. 215, 108427–108437 (2020).
2. Cascella, M., Rajnik, M., Aleem, A., Dulebohn, S. C. & Di Napoli, R. Features, Evaluation, and Treatment of Coronavirus (COVID-19). StatPearls 5, 1 (2021).
3. Saba, A. I. & Elsheikh, A. H. Forecasting the prevalence of COVID-19 outbreak in Egypt using nonlinear autoregressive artificial neural networks. Proc. Saf. Environ. Prot. 41, 1–8 (2020).
4. Elsheikh, A. H. et al. Deep learning-based forecasting model for COVID-19 outbreak in Saudi Arabia. Proc. Saf. Environ. Prot. 149, 223–233 (2021).
5. Al-Qaness, M. A. et al. Efficient artificial intelligence forecasting models for COVID-19 outbreak in Russia and Brazil. Proc. Saf. Environ. Prot. 149, 399–409 (2021).