Abstract
AbstractShift work with circadian disruption has been considered as a carcinogenic risk factor for skin cancer. The few prior studies that investigated the association between shift work and skin cancer have inconclusive results. Our main objective was to evaluate the associations between shift work and the risks of different types of skin cancer. We systematically searched PubMed, Web of Science, Cochrane Library, EMBASE and Science Direct until October 2018 for studies that included a relationship between shift work and skin cancer. Our search yielded 193 articles and 9 studies met the criteria for our review. The included studies involved 3,579,147 participants and 17,308 skin cancer cases. Overall, ever shift work, was associated with increased risk of melanoma (RR = 1.10, 95% CI = 1.05–1.16) and a significant decrease in the risk of BCC (RR = 0.90, 95% CI = 0.88–0.93). No association between shift work and the risk of SCC was detected. Interestingly, our dose response analysis demonstrated that the risk of melanoma cumulatively increases by 2% for every year of shift work (RR = 1.02; 95% CI = 1.00–1.03). In conclusion, shift work is associated with increased risk of melanoma and deceased risk of BCC. Further studies are needed to confirm our findings and to elucidate the related potential biological mechanisms.
Publisher
Springer Science and Business Media LLC
Reference51 articles.
1. Costa, G. Shift work and health: current problems and preventive actions. Saf. Health Work 1, 112–123 (2010).
2. Stevens, R. G. et al. Considerations of circadian impact for defining ‘shift work’ in cancer studies: IARC Working Group Report. Occup. Environ. Med. 68, 154–162 (2011).
3. McMenamin, T. M. A time to work: recent trends in shift work and flexible schedules. Monthly Labour review 130, 3–15 (2007).
4. Straif, K. et al. Carcinogenicity of shift-work, painting, and fire-fighting. Lancet Oncol. 8, 1065–1066 (2007).
5. Gutierrez, D. & Arbesman, J. Circadian dysrhythmias, physiological aberrations, and the link to skin cancer. Int. J. Mol. Sci. 17, 1–13 (2016).
Cited by
19 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献