Influence of Turkish origin on hematology reference intervals in the German population

Author:

Mayr Franz X.,Bertram Alexander,Cario Holger,Frühwald Michael C.,Groß Hans-Jürgen,Groening Arndt,Grützner Stefanie,Gscheidmeier Thomas,Hoffmann Reinhard,Krebs Alexander,Ruf Hans-Georg,Torge Antje,Woelfle Joachim,Razum Oliver,Rauh Manfred,Metzler Markus,Zierk Jakob

Abstract

AbstractReference intervals for laboratory test results have to be appropriate for the population in which they are used to be clinically useful. While sex and age are established partitioning criteria, patients’ origin also influences laboratory test results, but is not commonly considered when creating or applying reference intervals. In the German population, stratification for ethnicity is rarely performed, and no ethnicity-specific hematology reference intervals have been reported yet. In this retrospective study, we investigated whether specific reference intervals are warranted for the numerically largest group of non-German descent, individuals originating from Turkey. To this end, we analyzed 1,314,754 test results from 167,294 patients from six German centers. Using a name-based algorithm, 1.9% of patients were identified as originating from Turkey, in line with census data and the algorithm’s sensitivity. Reference intervals and their confidence intervals were calculated using an indirect data mining approach, and Turkish and non-Turkish reference limits overlapped completely or partially in nearly all analytes, regardless of age and sex, and only 5/144 (3.5%) subgroups’ reference limits showed no overlap. We therefore conclude that the current practice of using common reference intervals is appropriate and allows correct clinical decision-making in patients originating from Turkey.

Funder

Universitätsklinikum Erlangen

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

Reference39 articles.

1. Clinical and Laboratory Standards Institute (CLSI). Defining, Establishing, and Verifying Reference Intervals in the Clinical Laboratory; Approved Guideline-Third Edition, CLSI Document (Clinical and Laboratory Standards Institute, 2008).

2. Ozarda, Y. Reference intervals: Current status, recent developments and future considerations. Biochem. Med. 26, 5–11 (2016).

3. Tahmasebi, H., Trajcevski, K., Higgins, V. & Adeli, K. Influence of ethnicity on population reference values for biochemical markers. Crit. Rev. Clin. Lab. Sci. 55, 359–375 (2018).

4. Statistisches Bundesamt. Bevölkerung und Erwerbstätigkeit Bevölkerung mit Migrationshintergrund—Ergebnisse des Mikrozensus 2018 Fachserie 1 Reihe 2.2, Destatis, Wiesbaden (2019).

5. Lim, E., Miyamura, J. & Chen, J. J. Racial/ethnic-specific reference intervals for common laboratory tests: A comparison among Asians, blacks, hispanics, and white. Hawaii J. Med. Public Health 74, 302–310 (2015).

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3