Author:
Sequeros Celia Burgos,Hansen Thomas Folkmann,Westergaard David,Louloudis Ioannis,Kalamajski Sebastian,Röder Timo,Rohde Palle Duun,Schwinn Michael,Clemmensen Line Harder,Didriksen Maria,Nyegaard Mette,Hjalgrim Henrik,Nielsen Kaspar René,Bruun Mie Topholm,Ostrowski Sisse Rye,Erikstrup Christian,Mikkelsen Susan,Sørensen Erik,Banasik Karina,Bay Jakob,Boldsen Jens Kjærgaard,Brodersen Thorsten,Brunak Søren,Burgdorf Kristoffer,Chalmer Mona Ameri,Didriksen Maria,Dinh Khoa Manh,Dowsett Joseph,Erikstrup Christian,Feenstra Bjarke,Geller Frank,Gudbjartsson Daniel,Hansen Thomas Folkmann,Hindhede Lotte,Hjalgrim Henrik,Jacobsen Rikke Louise,Jemec Gregor,Jensen Bitten Aagaard,Kaspersen Katrine,Kjerulff Bertram Dalskov,Kogelman Lisette,Larsen Margit Anita Hørup,Louloudis Ioannis,Lundgaard Agnete,Mikkelsen Susan,Mikkelsen Christina,Nissen Ioanna,Nyegaard Mette,Ostrowski Sisse Rye,Pedersen Ole Birger Vestager,Pil Henriksen Alexander,Rohde Palle Duun,Rostgaard Klaus,Schwinn Michael,Stefansson Kari,Stefánsson Hreinn,Sørensen Erik,Thorsteinsdóttir Unnur,Thørner Lise Wegner,Topholm Bruun Mie,Ullum Henrik,Werge Thomas,Westergaard David,Pedersen Ole Birger Vestager,Brunak Søren,Banasik Karina,Giordano Giuseppe Nicola,
Abstract
AbstractSocial trust is a heritable trait that has been linked with physical health and longevity. In this study, we performed genome-wide association studies of self-reported social trust in n = 33,882 Danish blood donors. We observed genome-wide and local evidence of genetic similarity with other brain-related phenotypes and estimated the single nucleotide polymorphism-based heritability of trust to be 6% (95% confidence interval = (2.1, 9.9)). In our discovery cohort (n = 25,819), we identified one significantly associated locus (lead variant: rs12776883) in an intronic enhancer region of PLPP4, a gene highly expressed in brain, kidneys, and testes. However, we could not replicate the signal in an independent set of donors who were phenotyped a year later (n = 8063). In the subsequent meta-analysis, we found a second significantly associated variant (rs71543507) in an intergenic enhancer region. Overall, our work confirms that social trust is heritable, and provides an initial look into the genetic factors that influence it.
Publisher
Springer Science and Business Media LLC