Author:
Nam Min-Woo,Lee Yesung,Mun Eunchan,Lee Woncheol
Abstract
AbstractShift work has adverse health effects such as diabetes, cardiovascular disease, sleep disturbance, depression, and breast cancer. Gastro-esophageal reflux disease (GERD) results in lesions such as reflux esophagitis (RE) and Barrett’s esophagus. This study investigated the association between shift work and RE. A cohort study was conducted with 140,553 participants who were followed up at least once from 2012 to 2018. Type of working and shift types were collected using standardized questionnaires. Esophagogastroduodenoscopy (EGD) was performed by experienced endoscopists who were blinded to the aims of this study. According to the Los Angeles classification, RE was categorized based on the extent of esophageal mucosal breaks. During the 469,217.2 person-years of follow-up, 35,185 participants developed incident cases of RE. The multivariable adjusted hazard ratio (95% confidence intervals) for incident cases comparing shift work to fixed day work was 1.09 (1.04–1.13). This association was more strongly observed in the younger age group (18–39 years old) and the female group. In conclusion, shift work was significantly associated with the incidence of RE. Particularly, the results were more significant in the younger and female groups.
Publisher
Springer Science and Business Media LLC
Reference32 articles.
1. Agency, K. O. S. H.2017 5th Working Environment Survey, https://www.kosha.or.kr/kosha/data/registration.do?mode=view&boardNo=212&articleNo=327746&attachNo=#/list.
2. Torquati, L., Mielke, G. I., Brown, W. J. & Kolbe-Alexander, T. Shift work and the risk of cardiovascular disease. A systematic review and meta-analysis including dose-response relationship. Scand. J. Work Environ. Health 44, 229–238. https://doi.org/10.5271/sjweh.3700 (2018).
3. Lee, A. et al. Night shift work and risk of depression: Meta-analysis of observational studies. J. Korean Med. Sci. 32, 1091–1096. https://doi.org/10.3346/jkms.2017.32.7.1091 (2017).
4. Jehan, S. et al. Shift work and sleep: Medical implications and management. Sleep Med. Disord. Int. J. 1, 00008 (2017).
5. Hansen, J. Night shift work and risk of breast cancer. Curr. Environ. Health Rep. 4, 325–339. https://doi.org/10.1007/s40572-017-0155-y (2017).