Author:
Abudula Tuerdimaimaiti,Gauthaman Kalamegam,Mostafavi Azadeh,Alshahrie Ahmed,Salah Numan,Morganti Pierfrancesco,Chianese Angelo,Tamayol Ali,Memic Adnan
Abstract
AbstractNon-healing wounds have placed an enormous stress on both patients and healthcare systems worldwide. Severe complications induced by these wounds can lead to limb amputation or even death and urgently require more effective treatments. Electrospun scaffolds have great potential for improving wound healing treatments by providing controlled drug delivery. Previously, we developed fibrous scaffolds from complex carbohydrate polymers [i.e. chitin-lignin (CL) gels]. However, their application was limited by solubility and undesirable burst drug release. Here, a coaxial electrospinning is applied to encapsulate the CL gels with polycaprolactone (PCL). Presence of a PCL shell layer thus provides longer shelf-life for the CL gels in a wet environment and sustainable drug release. Antibiotics loaded into core–shell fibrous platform effectively inhibit both gram-positive and -negative bacteria without inducting observable cytotoxicity. Therefore, PCL coated CL fibrous gel platforms appear to be good candidates for controlled drug release based wound dressing applications.
Funder
Science and Technology Unit, King Abdulaziz University
Publisher
Springer Science and Business Media LLC
Cited by
38 articles.
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