Author:
Ran Shu,Jiang Zi-Xuan,He Xiao,Liu Yu,Zhang Yu-Xue,Zhang Lei,Pei Yu-Fang,Zhang Meng,Hai Rong,Gu Gui-Shan,Liu Bao-Lin,Tian Qing,Zhang Yong-Hong,Wang Jing-Yu,Deng Hong-Wen
Abstract
AbstractSarcopenia is characterized by low skeletal muscle, a complex trait with high heritability. With the dramatically increasing prevalence of obesity, obesity and sarcopenia occur simultaneously, a condition known as sarcopenic obesity. Fat mass and obesity-associated (FTO) gene is a candidate gene of obesity. To identify associations between lean mass and FTO gene, we performed a genome-wide association study (GWAS) of lean mass index (LMI) in 2207 unrelated Caucasian subjects and replicated major findings in two replication samples including 6,004 unrelated Caucasian and 38,292 unrelated Caucasian. We found 29 single nucleotide polymorphisms (SNPs) in FTO significantly associated with sarcopenia (combined p-values ranging from 5.92 × 10−12 to 1.69 × 10−9). Potential biological functions of SNPs were analyzed by HaploReg v4.1, RegulomeDB, GTEx, IMPC and STRING. Our results provide suggestive evidence that FTO gene is associated with lean mass.
Funder
National Natural Science Foundation of China
Publisher
Springer Science and Business Media LLC
Cited by
17 articles.
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