Author:
Eivazzadeh-Keihan Reza,Sadat Zahra,Aghamirza Moghim Aliabadi Hooman,Ganjali Fatemeh,Kashtiaray Amir,Salimi Bani Milad,Komijani Samira,Ahadian Mohammad Mahdi,salehpour Nabi,Ahangari Cohan Reza,Maleki Ali
Abstract
AbstractIn this study, the main focus was on designing and synthesizing a novel magnetic nanobiocomposite and its application in hyperthermia cancer treatment. Regarding this aim, sodium alginate (SA) hydrogel with CaCl2 cross-linker formed and modified by silk fibroin (SF) natural polymer and halloysite nanotubes (HNTs), followed by in situ Fe3O4 magnetic nanoparticles preparation. No important differences were detected in red blood cells (RBCs) hemolysis, confirming the high blood compatibility of the treated erythrocytes with this nanobiocomposite. Moreover, the synthesized SA hydrogel/SF/HNTs/Fe3O4 nanobiocomposite does not demonstrate toxicity toward HEK293T normal cell line after 48 and 72 h. The anticancer property of SA hydrogel/SF/HNTs/Fe3O4 nanobiocomposites against breast cancer cell lines was corroborated. The magnetic saturation of the mentioned magnetic nanobiocomposite was 15.96 emu g−1. The specific absorption rate (SAR) was measured to be 22.3 W g−1 by applying an alternating magnetic field (AMF). This novel nanobiocomposite could perform efficiently in the magnetic fluid hyperthermia process, according to the obtained results.
Publisher
Springer Science and Business Media LLC
Reference57 articles.
1. Eivazzadeh-Keihan, R. et al. Pectin-cellulose hydrogel, silk fibroin and magnesium hydroxide nanoparticles hybrid nanocomposites for biomedical applications. Int. J. Biol. Macromol. 192, 7–15 (2021).
2. Muir, V. G. & Burdick, J. A. Chemically modified biopolymers for the formation of biomedical hydrogels. Chem. Rev. 121, 10908–10949 (2020).
3. Eivazzadeh-Keihan, R. et al. Synthesis and characterization of cellulose, β-cyclodextrin, silk fibroinbased hydrogel containing copper-doped cobalt ferrite nanospheres and exploration of its biocompatibility. J. Nanostruct. Chem. 20, 1–11 (2022).
4. Eivazzadeh-Keihan, R. et al. Hybrid bionanocomposite containing magnesium hydroxide nanoparticles embedded in a carboxymethyl cellulose hydrogel plus silk fibroin as a scaffold for wound dressing applications. ACS Appl. Mater. Interfaces 13, 33840–33849 (2021).
5. Eivazzadeh-Keihan, R. et al. Alginate hydrogel-polyvinyl alcohol/silk fibroin/magnesium hydroxide nanorods: A novel scaffold with biological and antibacterial activity and improved mechanical properties. Int. J. Biol. Macromol. 162, 1959–1971 (2020).
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