Author:
Yao Kai-Xin,Lyu Hang,Liao Mei-Hua,Yang Lin,Gao Yin-Ping,Liu Qi-Bing,Wang Cheng-kun,Lu Ying-Mei,Jiang Guo-Jun,Han Feng,Wang Ping
Abstract
AbstractVascular dementia (VaD) is a complex disorder caused by reduced blood flow in the brain. However, there is no effective pharmacological treatment option available until now. Here, we reported that low-dose levamlodipine besylate could reverse the cognitive impairment in VaD mice model of right unilateral common carotid arteries occlusion (rUCCAO). Oral administration of levamlodipine besylate (0.1 mg/kg) could reduce the latency to find the hidden platform in the MWM test as compared to the vehicle group. Furthermore, vehicle-treated mice revealed reduced phospho-CaMKII (Thr286) levels in the hippocampus, which can be partially restored by levamlodipine besylate (0.1 mg/kg and 0.5 mg/kg) treatment. No significant outcome on microglia and astrocytes were observed following levamlodipine besylate treatment. This data reveal novel findings of the therapeutic potential of low-dose levamlodipine besylate that could considerably enhance the cognitive function in VaD mice.
Funder
National Natural Science Foundation of China
Natural Science Foundation of Zhejiang Province
Publisher
Springer Science and Business Media LLC
Cited by
3 articles.
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