Comprehensive characterization of glutamine synthetase-mediated selection for the establishment of recombinant CHO cells producing monoclonal antibodies
Author:
Publisher
Springer Science and Business Media LLC
Subject
Multidisciplinary
Link
http://www.nature.com/articles/s41598-018-23720-9.pdf
Reference41 articles.
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3. Beckmann, T. F. et al. Effects of high passage cultivation on CHO cells: a global analysis. Appl. Microbiol. Biotechnol. 94, 659–671 (2012).
4. Chusainow, J. et al. A study of monoclonal antibody-producing CHO cell lines: what makes a stable high producer? Biotechnol. Bioeng. 102, 1182–1196 (2009).
5. Fann, C. H., Guirgis, F., Chen, G., Lao, M. S. & Piret, J. M. Limitations to the amplification and stability of human tissue-type plasminogen activator expression by Chinese hamster ovary cells. Biotechnol. Bioeng. 69, 204–212 (2000).
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