Establishing associated risk factors, including fungal and parasitic infections among Malaysians living with schizophrenia
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Published:2024-01-03
Issue:1
Volume:14
Page:
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ISSN:2045-2322
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Container-title:Scientific Reports
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language:en
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Short-container-title:Sci Rep
Author:
Franklin Freddy,Rajamanikam Arutchelvan,Phang Wei Kit,Raju Chandramathi Samudi,Gill Jesjeet Singh,Francis Benedict,Sy-Cherng Woon Luke,Govind Suresh Kumar
Abstract
AbstractThe aetiology of schizophrenia is multifactorial, and the identification of its risk factors are scarce and highly variable. A cross-sectional study was conducted to investigate the risk factors associated with schizophrenia among Malaysian sub-population. A total of 120 individuals diagnosed with schizophrenia (SZ) and 180 non-schizophrenic (NS) individuals participated in a questionnaire-based survey. Data of complete questionnaire responses obtained from 91 SZ and 120 NS participants were used in statistical analyses. Stool samples were obtained from the participants and screened for gut parasites and fungi using conventional polymerase chain reaction (PCR). The median age were 46 years (interquartile range (IQR) 37 to 60 years) and 35 years (IQR 24 to 47.75 years) for SZ and NS respectively. Multivariable binary logistic regression showed that the factors associated with increased risk of SZ were age, sex, unemployment, presence of other chronic ailment, smoking, and high dairy consumption per week. These factors, except sex, were positively associated with the severity of SZ. Breastfed at infancy as well as vitamin and supplement consumption showed a protective effect against SZ. After data clean-up, fungal or parasitic infections were found in 98% (39/42). of SZ participants and 6.1% (3/49) of NS participants. Our findings identified non-modifiable risk factors (age and sex) and modifiable lifestyle-related risk factors (unemployment, presence of other chronic ailment, smoking, and high dairy consumption per week) associated with SZ and implicate the need for medical attention in preventing fungal and parasitic infections in SZ.
Funder
Ministry of Higher Education, Malaysia
Publisher
Springer Science and Business Media LLC
Subject
Multidisciplinary
Reference101 articles.
1. Chua, S. N. J. T. L. P. The economic cost of mental disorders in Malaysia. Lancet Psychiat. 7, e23 (2020).
2. Malays., I. f. P. H. J. M. H. National Health and Morbidity Survey 2015 (NHMS 2015). Vol. II: Non-Communicable Diseases, Risk Factors & Other Health Problems. 2, 185-186 (2015).
3. Chong, H. Y. et al. Global economic burden of schizophrenia: A systematic review. Neuropsychiatr. Dis. J. 12, 357 (2016).
4. Long, J. et al. The prevalence of schizophrenia in mainland China: Evidence from epidemiological surveys. Acta Vet. Scand. 130, 244–256 (2014).
5. Saha, S., Chant, D., Welham, J. & McGrath, J. A systematic review of the prevalence of schizophrenia. PLoS Med. 2, e141 (2005).