Abstract
AbstractAttention-deficit hyperactivity disorder (ADHD) is a complex brain development disorder characterized by hyperactivity/impulsivity and inattention. A major hypothesis of ADHD is a lag of maturation, which is supported mainly by anatomical studies evaluating cortical thickness. Here, we analyzed changes of topological characteristics of whole-brain metabolic connectivity in twelve SHR rats selected as ADHD-model rats by confirming behavior abnormalities using the marble burying test, open field test, and delay discounting task and 12 Wistar Kyoto rats as the control group, across development from 4 weeks old (childhood) and 6 weeks old (entry of puberty). A topological approach based on graph filtrations revealed a lag in the strengthening of limbic-cortical/subcortical connections in ADHD-model rats. This in turn related to impaired modularization of memory and reward-motivation associated regions. Using mathematical network analysis techniques such as single linkage hierarchical clustering and volume entropy, we observed left-lateralized connectivity in the ADHD-model rats at 6 weeks old. Our findings supported the maturational delay of metabolic connectivity in the SHR model of ADHD, and also suggested the possibility of impaired and compensative reconfiguration of information flow over the brain network.
Funder
National Research Foundation of Korea
Publisher
Springer Science and Business Media LLC
Reference55 articles.
1. Rhodes, S. M., Park, J., Seth, S. & Coghill, D. R. A comprehensive investigation of memory impairment in attention deficit hyperactivity disorder and oppositional defiant disorder. Journal of Child Psychology and Psychiatry 53, 128–137 (2012).
2. Skowronek, J. S., Leichtman, M. D. & Pillemer, D. B. Long‐term episodic memory in children with Attention‐Deficit/Hyperactivity Disorder. Learning Disabilities Research & Practice 23, 25–35 (2008).
3. Tarver, J., Daley, D. & Sayal, K. Attention-deficit hyperactivity disorder (ADHD): an updated review of the essential facts. Child: Care, Health and Development 40, 762–774 (2014).
4. Biederman, J. et al. Functional impairments in adults with self-reports of diagnosed ADHD: A controlled study of 1001 adults in the community. The Journal of Clinical Psychiatry 67, 524–540 (2006).
5. Shaw, P. et al. Attention-deficit/hyperactivity disorder is characterized by a delay in cortical maturation. Proceedings of the National Academy of Sciences of the United States of America 104, 19649–19654 (2007).
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