Targeting vascular disrupting agent-treated tumor microenvironment with tissue-penetrating nanotherapy

Author:

Sidorenko Valeria,Scodeller Pablo,Uustare Ain,Ogibalov Ivan,Tasa Andrus,Tshubrik Olga,Salumäe Liis,Sugahara Kazuki N.,Simón-Gracia Lorena,Teesalu Tambet

Funder

Ministerio de Ciencia e Innovación

Sihtasutus Archimedes

European Regional Development Fund

Eesti Teadusagentuur

EuroNanoMed III

TRANSCAN3

Publisher

Springer Science and Business Media LLC

Reference87 articles.

1. Siemann, D. W. et al. Differentiation and definition of vascular-targeted therapies. Clin. Cancer Res. 11, 416–420 (2005).

2. Siemann, D. W. The unique characteristics of tumor vasculature and preclinical evidence for its selective disruption by tumor-vascular disrupting agents. Cancer Treat. Rev. https://doi.org/10.1016/j.ctrv.2010.05.001 (2011).

3. Dark, G. G. et al. Combretastatin A-4, an agent that displays potent and selective toxicity toward tumor vasculature. Cancer Res. 57, 1829–1834 (1997).

4. Vincent, L. et al. Combretastatin A4 phosphate induces rapid regression of tumor neovessels and growth through interference with vascular endothelial-cadherin signaling. J. Clin. Investig. 115, 2992–3006. https://doi.org/10.1172/JCI24586 (2005).

5. Dowlati, A. et al. A phase I pharmacokinetic and translational study of the novel vascular targeting agent combretastatin A-4 phosphate on a single-dose intravenous schedule in patients with advanced cancer. Cancer Res. 62, 3408–3416 (2002).

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