Author:
Akamine Shoshin,Marutani Noriko,Kanayama Daisuke,Gotoh Shiho,Maruyama Riki,Yanagida Kanta,Sakagami Yukako,Mori Kohji,Adachi Hiroyoshi,Kozawa Junji,Maeda Norikazu,Otsuki Michio,Matsuoka Takaaki,Iwahashi Hiromi,Shimomura Iichiro,Ikeda Manabu,Kudo Takashi
Abstract
AbstractNeurofilament light chain (NfL) is a novel biomarker of neurodegenerative diseases. It is detectable in the peripheral blood, allowing low-invasive assessment of early signs of neurodegeneration. The level of NfL gradually increases with age; however, what other factors affect it remains unclear. The present study examined the association between blood NfL level and renal function among healthy participants undergoing a health check (n = 43, serum NfL) and patients with diabetes mellitus (n = 188, plasma NfL). All participants were 60 years of age or older; none were diagnosed with dementia. In each group, levels of blood NfL and serum creatinine significantly correlated (coefficient r = 0.50, 0.56). These associations remained statistically significant even after adjustment for age, sex, and body mass index. These findings indicate that blood NfL level might be partially affected by renal function. We recommend measuring renal function for a more precise evaluation of neuroaxonal damage, in particular, among older adults.
Funder
Japan Society for the Promotion of Science
Japan Agency for Medical Research and Development
SENSHIN Medical Research Foundation
Takeda Science Foundation
Mochida Memorial Foundation for Medical and Pharmaceutical Research
Publisher
Springer Science and Business Media LLC
Cited by
98 articles.
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