Author:
Csipo Tamas,Lipecz Agnes,Owens Cameron,Mukli Peter,Perry Jonathan W.,Tarantini Stefano,Balasubramanian Priya,Nyúl-Tóth Ádám,Yabluchanska Valeriya,Sorond Farzaneh A.,Kellawan J. Mikhail,Purebl György,Sonntag William E.,Csiszar Anna,Ungvari Zoltan,Yabluchanskiy Andriy
Abstract
AbstractSleep deprivation (SD) is a common condition and an important health concern. In addition to metabolic and cardiovascular risks, SD associates with decreases in cognitive performance. Neurovascular coupling (NVC, "functional hyperemia") is a critical homeostatic mechanism, which maintains adequate blood supply to the brain during periods of intensive neuronal activity. To determine whether SD alters NVC responses and cognitive performance, cognitive and hemodynamic NVC assessments were conducted prior to and 24 h post-SD in healthy young male individuals (n = 10, 27 ± 3 years old). Cognition was evaluated with a battery of tests from the Cambridge Neuropsychological Test Automated Battery (CANTAB). Hemodynamic components of NVC were measured by transcranial Doppler sonography (TCD) during cognitive stimulation, dynamic retinal vessel analysis (DVA) during flicker light stimulation, and functional near infrared spectroscopy (fNIRS) during finger tapping motor task. Cognitive assessments revealed impairments in reaction time and sustained attention after 24 h of SD. Functional NIRS analysis revealed that SD significantly altered hemodynamic responses in the prefrontal cortex and somatosensory cortex during a motor task. NVC-related vascular responses measured by DVA and TCD did not change significantly. Interestingly, TCD detected decreased task-associated cerebral blood flow (CBF) in the right middle cerebral artery in sleep deprived participants. Our results demonstrate that 24 h of SD lead to impairments in cognitive performance together with altered CBF and hemodynamic components of cortical NVC responses.
Funder
Geroscience Training Program in Oklahoma
National Institute on Aging
Presbyterian Health Foundation
National Institute of Neurological Disorders and Stroke
Oklahoma Center for the Advancement of Science and Technology
National Institute of General Medical Sciences
Cellular and Molecular GeroScience CoBRE
Publisher
Springer Science and Business Media LLC
Reference73 articles.
1. Hilmisson, H., Sveinsdottir, E., Lange, N. & Magnusdottir, S. Insomnia symptoms in primary care: A prospective study focusing on prevalence of undiagnosed co-morbid sleep disordered breathing. Eur. J. Intern. Med. 63, 19–26. https://doi.org/10.1016/j.ejim.2019.01.011 (2019).
2. Schutte-Rodin, S., Broch, L., Buysse, D., Dorsey, C. & Sateia, M. Clinical guideline for the evaluation and management of chronic insomnia in adults. J. Clin. Sleep Med. 4, 487–504 (2008).
3. Hirshkowitz, M. et al. National Sleep Foundation’s sleep time duration recommendations: methodology and results summary. Sleep Health 1, 40–43. https://doi.org/10.1016/j.sleh.2014.12.010 (2015).
4. National Center for Chronic Disease Prevention and Health Promotion, D. o. P. H. Short Sleep Duration Among US Adults. (2017).
5. Holt, J. et al. Indicators for Chronic Disease Surveillance—United States, 2013. MMWR. Recommendations and reports: Morbidity and mortality weekly report. Recommend. Rep. Cent. Dis. Control 64, 1–246 (2015).
Cited by
20 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献