Identification of New Shikonin Derivatives as Antitumor Agents Targeting STAT3 SH2 Domain
Author:
Publisher
Springer Science and Business Media LLC
Subject
Multidisciplinary
Link
http://www.nature.com/articles/s41598-017-02671-7.pdf
Reference38 articles.
1. Lai, P.-S. et al. A STAT inhibitor patent review: progress since 2011. Expert opinion on therapeutic patents 25, 1397–1421 (2015).
2. Miklossy, G., Hilliard, T. S. & Turkson, J. Therapeutic modulators of STAT signalling for human diseases. Nature reviews drug discovery 12, 611–629 (2013).
3. Furtek, S. L., Backos, D. S., Matheson, C. J. & Reigan, P. Strategies and Approaches of Targeting STAT3 for Cancer Treatment. ACS chemical biology 11, 308–318 (2016).
4. Bharadwaj, U. et al. Drug-repositioning screening identified piperlongumine as a direct STAT3 inhibitor with potent activity against breast cancer. Oncogene 34, 1341–1353 (2015).
5. Zhang, X. et al. A novel small-molecule disrupts Stat3 SH2 domain-phosphotyrosine interactions and Stat3-dependent tumor processes. Biochemical pharmacology 79, 1398–1409 (2010).
Cited by 26 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
1. Design, synthesis, and biological evaluation of novel napabucasin-melatonin hybrids as potent STAT3 inhibitors;Bioorganic Chemistry;2023-07
2. SAR Study and Molecular Mechanism Investigation of Novel Naphthoquinone-furan-2-cyanoacryloyl Hybrids with Antitumor Activity;Pharmaceutics;2022-10-01
3. Recent advances of antitumor shikonin/alkannin derivatives: A comprehensive overview focusing on structural classification, synthetic approaches, and mechanisms of action;European Journal of Medicinal Chemistry;2022-05
4. STAT3 pathway in cancers: Past, present, and future;MedComm;2022-03-23
5. Shikonin suppresses colon cancer cell growth and exerts synergistic effects by regulating ADAM17 and the IL‑6/STAT3 signaling pathway;International Journal of Oncology;2021-11-01
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"全球学者库"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前全球学者库共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2023 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3