Author:
Nakano Masahito,Yatsuhashi Hiroshi,Bekki Shigemune,Takami Yuko,Tanaka Yasuhito,Yoshimaru Yoko,Honda Koichi,Komorizono Yasuji,Harada Masaru,Shibata Michihiko,Sakisaka Shotaro,Shakado Satoshi,Nagata Kenji,Yoshizumi Tomoharu,Itoh Shinji,Sohda Tetsuro,Oeda Satoshi,Nakao Kazuhiko,Sasaki Ryu,Yamashita Tsutomu,Ido Akio,Mawatari Seiichi,Nakamuta Makoto,Aratake Yoshifusa,Matsumoto Shuichi,Maeshiro Tatsuji,Goto Takashi,Torimura Takuji
Abstract
AbstractWe examined the epidemiological trends, including the distribution of sex, age, and disease etiology, in HCC incident cases, over 24 years. Data of 20,547 HCC patients (1996–2019) were analyzed in this prospective study. We divided the study period into four 6-yearly quarters. HCC etiology was categorized as hepatitis B virus (HBV) infection, HBV + hepatitis C virus (HCV) infection, HCV infection, and both negative (non-BC). The incident cases of HCC per quarter of the study period were 4311 (21.0%), 5505 (26.8%), 5776 (28.1%), and 4955 (24.1%), sequentially. Overall, 14,020 (68.2%) patients were male. The number of HCC cases in patients < 60 years, 60–69 years, 70–79 years, and ≥ 80 years were 3711 (18.1%), 6652 (32.4%), 7448 (36.2%), and 2736 (13.3%), respectively. The average age of newly-diagnosed patients increased in each quarter. HCC was associated with HBV, HBV + HCV, and HCV infections and non-BC in 2997 (14.6%), 187 (0.9%), and 12,019 (58.5%), and 5344 (26.0%) cases, respectively. The number of HCV-associated cases decreased in each quarter, while that of non-BC-associated cases increased. HCC incident cases tend to increase in the elderly and in non-BC patients; in contrast, HCC incident cases due to HCV tend to decrease.
Publisher
Springer Science and Business Media LLC