Author:
Lagerquist Marie K.,Gustafsson Karin L.,Henning Petra,Farman Helen,Wu Jianyao,Sjögren Klara,Koskela Antti,Tuukkanen Juha,Ohlsson Claes,Wernstedt Asterholm Ingrid,Grahnemo Louise
Abstract
AbstractObesity has previously been thought to protect bone since high body weight and body mass index are associated with high bone mass. However, some more recent studies suggest that increased adiposity negatively impacts bone mass. Here, we aimed to test whether acute loss of adipose tissue, via adipocyte apoptosis, alters bone mass in age-related obese mice. Adipocyte apoptosis was induced in obese male FAT-ATTAC mice through AP20187 dimerizer-mediated activation of caspase 8 selectively in adipocytes. In a short-term experiment, dimerizer was administered to 5.5 month-old mice that were terminated 2 weeks later. At termination, the total fat mass weighed 58% less in dimerizer-treated mice compared with vehicle-treated controls, but bone mass did not differ. To allow for the detection of long-term effects, we used 9-month-old mice that were terminated six weeks after dimerizer administration. In this experiment, the total fat mass weighed less (− 68%) in the dimerizer-treated mice than in the controls, yet neither bone mass nor biomechanical properties differed between groups. Our findings show that adipose tissue loss, despite the reduced mechanical loading, does not affect bone in age-related obese mice. Future studies are needed to test whether adipose tissue loss is beneficial during more severe obesity.
Funder
Gustaf V’s 80-years fund
Swedish research council
NovoNordisk Foundation
IngBritt and Arne Lundgren Foundation
The Swedish Diabetes Foundation
O.E. and Edla Johansson’s Scientific Foundation
Wilhelm and Martina Lundgrens’s Science Fund
Längmanska Foundation
Sigurd and Elsa Golje’s Memory Foundation
Lars Hierta’s Memory Foundation
The Sahlgrenska University Hospital foundation
University of Gothenburg
Publisher
Springer Science and Business Media LLC
Cited by
5 articles.
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