Author:
Tan Kai,Zhang Changhui,He Zuomei,Zeng Puhua
Abstract
Abstractβ-Elemene is the main active ingredient in Curcumae Rhizoma that exerts antitumour effects. Anoikis affects tumour development through various biological pathways in non-small cell lung cancer (NSCLC), but the regulation between β-elemene and anoikis remains to be explored. First, we explored the molecular expression patterns of anoikis-associated genes (AAGs) using consensus clustering and characterized the impact of AAGs on patient prognosis, clinical characteristics, and genomic instability. In addition, we revealed that AAG regulatory genes have rich interactions with β-elemene targets, and established a lncRNA-miRNA-mRNA network to explain the effect of β-elemene on anoikis. Finally, to reveal the prognostic effect of their correlation, the prognostic scoring model and clinical nomogram of β-elemene and anoikis were successfully established by least absolute shrinkage and selection operator (LASSO) and random forest algorithms. This prognostic scoring model containing noncoding RNA (ncRNA) can indicate the immunotherapy and mutational landscape, providing a novel theoretical basis and direction for the study of the antitumour mechanism of β-elemene in NSCLC patients.
Funder
National Natural Science Foundation of China Youth Science Foundation Project
Natural Science Foundation of Hunan Province Youth Fund
Youth Fund of Hunan Provincial Administration of Traditional Chinese Medicine
National Natural Science Foundation of China
Young Qihuang Scholars Talent Project of National Administration of Traditional Chinese Medicine
Top Technology Leading Talents Project of Hunan Province
Key R&D projects in Hunan Province
Natural Science Foundation of Hunan Province
Hunan Provincial Health Commission Traditional Chinese Medicine Shennong Leading Talent Project
Hunan Provincial Engineering Research Center of Anti-tumour Chinese Medicine Creation Technology Project
Publisher
Springer Science and Business Media LLC