Author:
Nakagawa Shinichi,Okada Rintaro,Kushioka Junichi,Kodama Joe,Tsukazaki Hiroyuki,Bal Zeynep,Tateiwa Daisuke,Ukon Yuichiro,Hirai Hiromasa,Makino Takahiro,Takenaka Shota,Okada Seiji,Kaito Takashi
Abstract
AbstractThe effects and inflammation-related side effects of bone morphogenetic protein (BMP)-2 on posterior lumbar interbody fusion are controversial. One of the potential causes for the inconsistent results is the uncontrolled release of BMP-2 from the collagen carrier. Therefore, BMP delivery systems that support effective bone regeneration while attenuating the side effects are strongly sought for. We developed NOVOSIS putty (NP), a novel composite material of hydroxyapatite (HA), beta-tricalcium phosphate (β-TCP)/hydrogel, and BMP-2, which can sustainably release BMP-2 over 2 weeks. This study was aimed at comparing the effects and side effects of NP and collagen sponge (CS) containing BMP-2 using a rat caudal intervertebral fusion model. The fusion rates of NP with low and high doses of BMP-2 were significantly higher than those of an iliac bone (IB) graft, but those of CS with low and high doses of BMP-2 were not different from those of the IB graft. Furthermore, the incidences of ectopic bone formation and soft tissue swelling were significantly lower in the NP group than in the CS group. The HA/β-TCP/hydrogel carrier enabled superior bone induction with low-dose BMP-2 and decreased the incidence of side effects caused by high-dose BMP-2 vis-à-vis the collagen carrier.
Funder
Nippon Zoki Pharmaceutical
Publisher
Springer Science and Business Media LLC
Reference31 articles.
1. Burkus, J. K., Gornet, M. F., Dickman, C. A. & Zdeblick, T. A. Anterior lumbar interbody fusion using rhBMP-2 with tapered intervertebral cages. J. Spinal Disord. Tech. 15, 337–349. https://doi.org/10.1097/00024720-200210000-00001 (2002).
2. Ong, K. L. et al. Off-label use of bone morphogenetic proteins in the United States using administrative data. Spine (Phila Pa 1976) 35, 1794–1800. https://doi.org/10.1097/BRS.0b013e3181ecf6e4 (2010).
3. Cahill, K. S., Chi, J. H., Day, A. & Claus, E. B. Prevalence, complications, and hospital charges associated with use of bone-morphogenetic proteins in spinal fusion procedures. JAMA 302, 58–66. https://doi.org/10.1001/jama.2009.956 (2009).
4. Hustedt, J. W. & Blizzard, D. J. The controversy surrounding bone morphogenetic proteins in the spine: A review of current research. Yale J. Biol. Med. 87, 549–561 (2014).
5. Tannoury, C. A. & An, H. S. Complications with the use of bone morphogenetic protein 2 (BMP-2) in spine surgery. Spine J. 14, 552–559. https://doi.org/10.1016/j.spinee.2013.08.060 (2014).
Cited by
6 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献