Author:
Liu Yuan-jie,Li Jie-pin,Li Hui-ru,Zeng Shu-hong,Chen Yu-gen,Han Mei,Ye Qian-wen,Zhou Jin-yong,Liu Shen-lin,Zou Xi
Abstract
AbstractThe TBC (Tre-2/Bub2/Cdc16, TBC) structural domain is now considered as one of the factors potentially regulating tumor progression. However, to date, studies on the relationship between TBC structural domains and tumors are limited. In this study, we identified the role of TBC1 domain family member 8 (TBC1D8) as an oncogene in colorectal cancer (CRC) by least absolute shrinkage and selection operator (LASSO) and Cox regression analysis, showing that TBC1D8 may independently predict CRC outcome. Functional enrichment and single-cell analysis showed that TBC1D8 levels were associated with hypoxia. TBC1D8 levels were also positively correlated with M2 macrophage infiltration, which may have a complex association with hypoxia. Taken together, these results show that the TBC1D8 gene is involved in colorectal carcinogenesis, and the underlying molecular mechanisms may include hypoxia and immune cell infiltration.
Funder
Advantageous Disciplines Program of Nanjing University of Chinese Medicine
Science and Technology Project of Affiliated Hospital of Nanjing University of Chinese Medicine
Jiangsu Province Postgraduate Research Innovation Program Project
State Administration of Chinese Medicine Project
Foundation Research Project of Jiangsu Province
China National Natural Scientific Fund
Jiangsu Provincial Science and Technology Department Project
Publisher
Springer Science and Business Media LLC