Author:
Xu Jiawei,Zhang Yunpeng,Gan Rong,Liu Zhuoqi,Deng Yan
Abstract
AbstractRetinopathy of Prematurity (ROP) is a multifactorial disease characterized by abnormal retinal vascular growth in premature infants, which is one of the leading causes of childhood blindness. Lactic acid metabolism may play an imperative role in the development of ROP, but there are still few relevant studies. Our team use a dataset GSE158799 contained 284 genes in 3 P17_OIR mice and 3 P30_OIR mice to identify 41 potentially differentially expressed lactate metabolism-related genes (LMRGs) related to ROP. Then through bioinformatics analysis, we strive to reveal the interaction, the enriched pathways and the immune cell infiltration among these LMRGs, and predict their functions and internal mechanisms. These DEGs may regulate lactate metabolism, leading to the changes of metabolism and immunity, thereby inducing the development of ROP. Our results will expand our understanding of the intrinsic mechanism of ROP and may be helpful for the directions for treatment of ROP in the future.
Funder
National Natural Science Foundation of China
Natural Science Foundation in Jiangxi Province
the Project of the Science and Technology Department of Jiangxi province
the Science and Technology Project of Jiangxi Provincial Health Commission
the Innovation and Entrepreneurship training Program for college students
Publisher
Springer Science and Business Media LLC