Identification of alkaline pH optimum of human glucokinase because of ATP-mediated bias correction in outcomes of enzyme assays
Author:
Funder
Univerzita Karlova v Praze
Publisher
Springer Science and Business Media LLC
Subject
Multidisciplinary
Link
http://www.nature.com/articles/s41598-019-47883-1.pdf
Reference39 articles.
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2. Lin, H. et al. Discovery of a novel 2,6-disubstituted glucosamine series of potent and selective hexokinase 2 inhibitors. ACS Med. Chem. Lett. 7, 217–222 (2015).
3. Zhang, H. N. et al. Systematic identification of arsenic-binding proteins reveals that hexokinase-2 is inhibited by arsenic. Proc. Natl. Acad. Sci. USA 112, 15084–15089 (2015).
4. Fujieda, H. et al. Discovery of a potent glucokinase activator with a favorable liver and pancreas distribution pattern for the treatment of type 2 diabetes mellitus. Eur. J. Med. Chem. 156, 269–294 (2018).
5. Salas, J., Salas, M., Vinuela, E. & Sols, A. Glucokinase of rabbit liver. J. Biol. Chem. 240, 1014–1018 (1965).
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