Author:
Kakihara Nahoko,Sato Momoko,Shirai Ayaki,Koguchi Mizuki,Yamauchi Shiori,Nakano Toshimichi,Sasamoto Ryuta,Sato Hideyo
Abstract
AbstractRadiation therapy used in the treatment of cancer causes skin damage, and no method of care has been established thus far. Recently, it has become clear that sericin derived from silkworm cocoons has moisturizing and antioxidant functions. In addition, green cocoon-derived sericin, which is rich in flavonoids, may have enhanced functions. However, whether this green cocoon-derived sericin can reduce radiotherapy-induced skin damage is unclear. In the present study, we aimed at establishing care methods to reduce skin cell damage caused by X-irradiation using green cocoon-derived sericin. We investigated its effect on human keratinocytes using lactate dehydrogenase activity to indicate damage reduction. Our results showed that green cocoon-derived sericin reduced cell damage caused by X-irradiation. However, this effect was not observed when cells were treated before X-irradiation or with a sericin derived from white cocoons. In addition, green cocoon-derived sericin decreased the levels of reactive oxygen species and lipid peroxidation. Our results suggest that green cocoon sericin mitigates the damaging effect of X-irradiation on cells, hence presenting potential usefulness in reducing skin damage from radiation therapy and opening new avenues in the care of cancer patients.
Publisher
Springer Science and Business Media LLC
Reference26 articles.
1. Kopelson, G., Harisiadis, L., Tretter, P. & Chang, C. H. The role of radiation therapy in cancer of the extra-hepatic biliary system: An analysis of thirteen patients and a review of the literature of the effectiveness of surgery, chemotherapy and radiotherapy. Int. J. Radiat. Oncol. Biol. Phys. 2, 883–894 (1977).
2. Shah, C., Bauer-Nilsen, K., McNulty, R. H. & Vicini, F. Novel radiation therapy approaches for breast cancer treatment. Semin. Oncol. 47, 209–216 (2020).
3. Soriano, J. L., Calpena, A. C., Souto, E. B. & Clares, B. Therapy for prevention and treatment of skin ionizing radiation damage: A review. Int. J. Radiat. Biol. 95, 537–553 (2019).
4. Kawamori, J. et al. Effect of heparinoid moisturizer on quality of life in patients with acute radiation skin damage following hypofractionated radiation therapy after breast-conserving surgery: A randomized controlled study. Breast Cancer (Dove Med Press). 13, 743–753 (2021).
5. Hegedus, F. & Schwartz, R. A. Cutaneous radiation damage: Updating a clinically challenging concern. G Ital Dermatol Venereol. 154, 550–556 (2019).