Abstract
AbstractFatigue related to Multiple Sclerosis (MS) is considered a multidimensional symptom, manifesting in several dimensions such as physical, cognitive, and psychosocial fatigue. This study investigated in 264 patients with severe primary MS-related fatigue (median MS duration 6.8 years, mean age 48.1 years, 75% women) whether subgroups can be distinguished based on these dimensions. Subsequently, we tested whether MS-related fatigue consists of a single common unidimensional factor. Subscale scores on four self-reported fatigue questionnaires, including the Checklist of Individual Strength, the Modified Fatigue Impact Scale, the Fatigue Severity Scale and the SF36 vitality, were used in a cluster analysis to identify patients with similar fatigue characteristics. Next, all 54 items were included in exploratory factor analysis to test unidimensionality. Study results show that in patients with a treatment indication for primary MS-related fatigue, fatigue profiles are based on severity and not on the various dimensions of fatigue. The three profiles found, suggested one underlying fatigue dimension, but this could not be confirmed. Factor analysis of all 54 items resulted in 8 factors, confirming the multidimensional construct of the included fatigue questionnaires.
Publisher
Springer Science and Business Media LLC
Reference53 articles.
1. Kister, I. et al. Natural history of multiple sclerosis symptoms. Int. J. MS Care. 15, 146–158 (2013).
2. Stuke, K. et al. Symptomatology of MS: results from the German MS Registry. J. Neurol. 256, 1932–1935 (2009).
3. Wade, D., Young, K. & Lowe, D. National Audit of Services for People with Multiple Sclerosis 2008. (Royal College of Physicians and Multiple Sclerosis Trust, 2008). Available via, https://www.rcplondon.ac.uk/projects/outputs/national-audit-services-people-multiple-sclerosis-archived-2008-reports. Accessed 7 January 2019.
4. Weiland, T. J. et al. Clinically significant Fatigue: Prevalence and Associated Factors in an International Sample of Adults with Multiple Sclerosis Recruited via the Internet. PLoS One. 10, e0115541 (2015).
5. Chaudhuri, A. & Behan, P. O. Fatigue in neurological disorders. Lancet. 363, 978–988 (2004).
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