Dihydromyricetin improves social isolation-induced cognitive impairments and astrocytic changes in mice

Author:

Watanabe Saki,Omran Alzahra Al,Shao Amy S.,Xue Chen,Zhang Zeyu,Zhang Jifeng,Davies Daryl L.,Shao Xuesi M.,Watanabe Junji,Liang Jing

Abstract

AbstractSocial isolation induces stress, anxiety, and mild cognitive impairment that could progress towards irreversible brain damage. A probable player in the mechanism of social isolation-induced anxiety is astrocytes, specialized glial cells that support proper brain function. Using a social isolation mouse model, we observed worsened cognitive and memory abilities with reductions of Object Recognition Index (ORI) in novel object recognition test and Recognition Index (RI) in novel context recognition test. Social isolation also increased astrocyte density, reduced astrocyte size with shorter branches, and reduced morphological complexity in the hippocampus. Dihydromyricetin, a flavonoid that we previously demonstrated to have anxiolytic properties, improved memory/cognition and restored astrocyte plasticity in these mice. Our study indicates astrocytic involvement in social isolation-induced cognitive impairment as well as anxiety and suggest dihydromyricetin as an early-stage intervention against anxiety, cognitive impairment, and potential permanent brain damage.

Funder

Saudi Arabian Cultural Mission

Army Health Professions Scholarship

National Institutes of Health

Carefree Biotechnology Foundation

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

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