High-speed rail model reveals the gene tandem amplification mediated by short repeated sequence in eukaryote-Reference-Cited by-全球学者库

High-speed rail model reveals the gene tandem amplification mediated by short repeated sequence in eukaryote

Published:2022-02-10 Issue:1 Volume:12 Page:
ISSN:2045-2322
Container-title:Scientific Reports
language:en
Short-container-title:Sci Rep

Author:

Chen Haidi,Xue Jingwen,Zhang Zhenghou,Zhang Geyu,Xu Xinyuan,Li He,Zhang Ruxue,Ullah Najeeb,Chen Lvxing,Amanullah ,Zang Zhuqing,Lai Shanshan,He Ximiao,Li Wei,Guan Miao,Li Jingyi,Chen Liangbiao,Deng Cheng

Abstract

AbstractThe occurrence of gene duplication/amplification (GDA) provide potential material for adaptive evolution with environmental stress. Several molecular models have been proposed to explain GDA, recombination via short stretches of sequence similarity plays a crucial role. By screening genomes for such events, we propose a “SRS (short repeated sequence) *N + unit + SRS*N” amplified unit under USCE (unequal sister-chromatid exchange) for tandem amplification mediated by SRS with different repeat numbers in eukaryotes. The amplified units identified from 2131 well-organized amplification events that generate multi gene/element copy amplified with subsequent adaptive evolution in the respective species. Genomic data we analyzed showed dynamic changes among related species or subspecies or plants from different ecotypes/strains. This study clarifies the characteristics of variable copy number SRS on both sides of amplified unit under USCE mechanism, to explain well-organized gene tandem amplification under environmental stress mediated by SRS in all eukaryotes.

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

Link

https://www.nature.com/articles/s41598-022-06250-3.pdf

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