Author:
Wu Fei-Fei,Zhang Kun-Long,Wang Zheng-Mei,Yang Yi,Li Shao-Hua,Wang Jia-Qi,Ma Jin,Yang Yan-Ling,Zhang Hai-Feng,Wang Ya-Yun
Abstract
AbstractSimulated hypobaric hypoxia (SHH) training has been used to enhance running performance. However, no studies have evaluated the effects of a single SHH exposure on healthy mice performance and analyzed the changes of mitochondria-related genes in the central nervous system. The current study used a mouse decompression chamber to simulate mild hypobaric hypoxia at the high altitude of 5000 m or severe hypobaric hypoxia at 8000 m for 16 h (SHH5000 & SHH8000, respectively). Then, the mouse behavioral tests were recorded by a modified Noldus video tracking. Third, the effects of SHH on 8 mitochondria-related genes of Drp1, Mfn1, Mfn2, Opa1, TFAM, SGK1, UCP2 and UCP4, were assessed in cerebellum, hippocampus and gastrocnemius muscles. The results have shown that a single mild or severe HH improves healthy mice performance. In cerebellum, 6 of all 8 detected genes (except Mfn2 and UCP4) did not change after SHH. In hippocampus, all detected genes did not change after SHH. In muscles, 7 of all 8 detected genes (except Opa1) did not change after SHH. The present study has indicated the benefit of a single SHH in healthy mice performance, which would due to the stabilized mitochondria against a mild stress state.
Funder
the National Natural Science Foundation of China
Key R
Scientific and technological research projects on major issues in aviation medicine
State Key Laboratory of Military Stomatology Open project
Publisher
Springer Science and Business Media LLC
Reference43 articles.
1. Kicken, C. H. et al. Hypobaric hypoxia causes elevated thrombin generation mediated by FVIII that is balanced by decreased platelet activation. Thromb. Haemost. 118, 883–892. https://doi.org/10.1055/s-0038-1641566 (2018).
2. West, J. B. Physiological effects of chronic hypoxia. N. Engl. J. Med. 376, 1965–1971. https://doi.org/10.1056/NEJMra1612008 (2017).
3. Peacock, A. J. ABC of oxygen Oxygen at high altitude. (1998).
4. Wilson, M. H., Newman, S. & Imray, C. H. The cerebral effects of ascent to high altitudes. Lancet Neurol. 8, 175–191. https://doi.org/10.1016/S1474-4422(09)70014-6 (2009).
5. Wu, X., Li, X., Han, L., Wang, T. & Wei, Y. Effects of acute moderate hypoxia on human performance of arithmetic. Space Med. Med. Eng. (Beijing) 11, 391–395 (1998).
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