Author:
Moazen Mehran,Hejazi Mahbubeh,Savery Dawn,Jones Dominic,Marghoub Arsalan,Alazmani Ali,Pauws Erwin
Abstract
AbstractChildren with syndromic forms of craniosynostosis undergo a plethora of surgical interventions to resolve the clinical features caused by the premature fusion of cranial sutures. While surgical correction is reliable, the need for repeated rounds of invasive treatment puts a heavy burden on the child and their family. This study explores a non-surgical alternative using mechanical loading of the cranial joints to prevent or delay craniofacial phenotypes associated with Crouzon syndrome. We treated Crouzon syndrome mice before the onset of craniosynostosis by cyclical mechanical loading of cranial joints using a custom designed set-up. Cranial loading applied to the frontal bone partially restores normal skull morphology, significantly reducing the typical brachycephalic appearance. This is underpinned by the delayed closure of the coronal suture and of the intersphenoidal synchondrosis. This study provides a novel treatment alternative for syndromic craniosynostosis which has the potential to be an important step towards replacing, reducing or refining the surgical treatment of all craniosynostosis patients.
Funder
Newlife the Charity for Disabled Children
Royal Academy of Engineering
Engineering and Physical Sciences Research Council
Great Ormond Street Hospital Charity
Publisher
Springer Science and Business Media LLC
Cited by
4 articles.
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