Author:
Gao Yanhang,Li Yanqing,Liu Xiaowen,Zhang Tong,Yu Ge,Wang Yang,Shi Ying,Chi Xiumei,Wang Xiaomei,Gao Xiuzhu,Wu Ruihong,Zhang Yingyu,Hang Lei,Sun Shijuan,Guan Yazhe,Xu Ying,Meng Jing,Liu Xu,Jiang Chang,Ma Heming,Luo Liting,Yan Qi,Yin Xin,Peng Fei,Zhi Yixiao,Qu Weige,Zhang Xia,Ren Tianqi,Liu Lili,Zhao Jinming,Zhang Feiyu,Yakepu Adila,Pan Yu,Xu Hongqin,Niu Junqi
Abstract
AbstractIn China, the prevalence of Clonorchis sinensis (C. sinensis) infections is only evaluated at the provincial level by national sampling surveys, and data from villages and counties are still lacking. In this study, we conducted a cross-sectional survey in 10 villages located along the Lalin River in northeast China. Clonorchiasis was diagnosed using a modified Kato–Katz method that detects the C. sinensis egg in stools. A total of 3,068 persons were screened and 2,911 were recruited for the study. Overall, the prevalence of C. sinensis infection was 29.3%. Among 175 participants who were cured after antiparasitic treatment, 54 (30.86%) were re-infected in this survey. After calibration of potential confounders, male gender, occupation as a farmer, smoking, and occasionally or frequently eating raw fish were independent risk factors for C. sinensis infection. The results of laboratory examinations in the C. sinensis/hepatitis B or C virus co-infection group were similar to those in the hepatitis B or C virus mono-infection groups. In conclusion, C. sinensis is highly endemic in villages along the Lalin River, and the primary route of infection is the consumption of raw freshwater fish. Co-infection with C. sinensis did't aggravate the clinical manifestations of viral hepatitis in this cross-sectional study.
Funder
the National key research plan “precision medicine research” key project
the National Natural Science Foundation of China
the National Science and Technology Major Project
the JLU Norman Bethune research plan
the National Natural Science Foundation of Jilin Province
Program for JLU Science and Technology Innovative Research Team
Publisher
Springer Science and Business Media LLC
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