Testicular steroidogenesis is suppressed during experimental autoimmune encephalomyelitis in rats

Author:

Milosevic Ana,Bjelobaba Ivana,Bozic Iva D.,Lavrnja Irena,Savic Danijela,Tesovic Katarina,Jakovljevic Marija,Stojilkovic Stanko S.,Janjic Marija M.

Abstract

AbstractMultiple sclerosis (MS) is an autoimmune disease that usually occurs during the reproductive years in both sexes. Many male patients with MS show lower blood testosterone levels, which was also observed in male rats during experimental autoimmune encephalomyelitis (EAE), an animal model of MS. To better understand the causes of decreased testosterone production during EAE, we investigated the expression status of genes and proteins associated with steroidogenesis in the testes. No changes in the number of interstitial cells were observed in EAE animals, but the expression of the insulin-like 3 gene was reduced at the peak of the disease, implying that the Leydig cell functional capacity was affected. Consistent with this finding, the expression of most steroidogenic enzyme genes and proteins was reduced during EAE, including StAR, CYP11A1, CYP17A1 and HSD3B. No signs of testicular inflammation were observed. Recovery of steroidogenesis was observed after injection of hCG, the placental gonadotropin, or buserelin acetate, a gonadotropin-releasing hormone analogue, at the peak of EAE. Together, our results are consistent with the hypothesis that impaired testicular steroidogenesis originates upstream of the testes and that low serum LH is the main cause of decreased testosterone levels during EAE.

Funder

Ministarstvo Prosvete, Nauke i Tehnološkog Razvoja

Intramural Research Program of the National Institute of Child Health and Human Development, NIH

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

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