Author:
Qian Naisi,Yang Qing,Chen Lei,Jin Shan,Qiao Jiaying,Cai Renzhi,Wu Chunxiao,Yu Huiting,Gu Kai,Wang Chunfang
Abstract
AbstractThe prevalence of high birth weight or large for gestational age (LGA) infants is increasing, with increasing evidence of pregnancy-related factors that may have long-term impacts on the health of the mother and baby. We aimed to determine the association between excessive fetal growth, specifically LGA and macrosomia, and subsequent maternal cancer by performing a prospective population-based cohort study. The data set was based on the Shanghai Birth Registry and Shanghai Cancer Registry, with medical records from the Shanghai Health Information Network as a supplement. Macrosomia and LGA prevalence was higher in women who developed cancer than in women who did not. Having an LGA child in the first delivery was associated with a subsequently increased risk of maternal cancer (hazard ratio [HR] = 1.08, 95% confidence interval [CI] 1.04–1.11). Additionally, in the last and heaviest deliveries, there were similar associations between LGA births and maternal cancer rates (HR = 1.08, 95% CI 1.04–1.12; HR = 1.08, 95% CI 1.05–1.12, respectively). Furthermore, a substantially increased trend in the risk of maternal cancer was associated with birth weights exceeding 2500 g. Our study supports the association between LGA births and increased risks of maternal cancer, but this risk requires further investigation.
Funder
Key Young Talents Training Program for Shanghai Disease Control and Prevention
National Natural Science Foundation of China
Publisher
Springer Science and Business Media LLC
Reference33 articles.
1. Markestad, T. et al. Prediction of fetal growth based on maternal serum concentrations of human chorionic gonadotropin, human placental lactogen and estriol. Acta Obstet. Gynecol. Scand. Suppl. 165(1), 50–55 (1997).
2. Gardner, M. et al. Maternal serum concentrations of human placental lactogen, estradiol and pregnancy specific beta 1-glycoprotein and fetal growth retardation. Acta Obstet. Gynecol. Scand. Suppl. 172(1), 56 (1995).
3. Troisi, R. et al. The role of pregnancy, perinatal factors and hormones in maternal cancer risk: A review of the evidence. J. Intern. Med. 283(5), 430–445 (2018).
4. Swerdlow, A. J., Wright, L. B., Schoemaker, M. J. & Jones, M. E. Maternal breast cancer risk in relation to birthweight and gestation of her offspring. Breast Cancer Res. 20(1), 110 (2018).
5. Crump, C. et al. Fetal growth and subsequent maternal risk of thyroid cancer. Int. J. Cancer 138(5), 1085–1093 (2016).