Abstract
AbstractThe objective of this investigation was to evaluate the activity of the suprahyoid musculature during swallowing and to correlate the findings with the degree of megaesophagus, oral and pharyngeal videofluoroscopy and esophageal manometry in patients with achalasia caused by Chagas’ disease. Twenty-nine patients with positive serology for Trypanosoma cruzi and dysphagia (Chagas’ disease group) and 29 individuals matched by sex and age (control group) participated in the study. Surface electromyography of the suprahyoid musculature and videofluoroscopy during swallowing of paste and liquid consistencies were performed. Canonical correlation analysis of the MANOVA test results showed that the Chagas’ disease group had lower electromyographic activity when compared with controls. Overlapping circles of radiological findings were found for megaesophagus. The Spearman test showed a positive correlation between the electromyographic activity in the maximum voluntary isometric contraction and the time of pharyngeal transit for both liquid (p = 0.014) and paste (p = 0.047). The logistic regression test showed no association between electromyographic activity of the suprahyoid muscles and esophageal manometry results (p > 0.05). In conclusion, individuals with chagasic megaesophagus have reduced electromyographic activity of the suprahyoid muscles during swallowing, in addition to a greater recruitment of the suprahyoid musculature with increased pharyngeal transit time.
Publisher
Springer Science and Business Media LLC
Reference35 articles.
1. WHO. Chagas disease: American trypanosomiasis. WorldHealthOrganization. Available from, http://www.who.int/mediacentre/factsheets/fs340/en/ (2017).
2. Salvador, F. et al. Trypanosomacruzi infection in a non-endemic country: epidemiological and clinical profile. Clin. Micro. Biol. Infect. 20, 706–712 (2013).
3. Macedo, A. M. & Segatto, M. Implications of Trypanosomacruzi intraspecific diversity in the pathogenesis of Chagas’ disease. In: Tibayrenc, M., Telleria, J. (ed). American Trypanosomiasis Chagas Disease One Hundred Years of Research. (ed. Elsevier, Amsterdam) 489–522 (2010).
4. Andrade, C. M. et al. Chagas’ disease: morbidity profile in an endemic area of Northeastern Brazil. Rev. Soc. Bras. Med. Trop. 48, 706–715 (2015).
5. Gasparim, A. Z., Rossoni, D. F., Fontes, C. E. R. & Toledo, M. J. O. Epidemiological and clinical profile of patients with Chagas’ disease in the central north of Paraná state, Southeast Brazil. Rev. Soc. Bras. Med. Trop. 51, 1–12 (2018).
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献
1. Digestive Disorders in Chagas Disease: Megaesophagus and Chagasic Megacolon;Chagas Disease - From Cellular and Molecular Aspects of Trypanosoma cruzi-Host Interactions to the Clinical Intervention;2022-07-13