Author:
Charoenphandhu Narattaphol,Sooksawanwit Supagarn,Aeimlapa Ratchaneevan,Thonapan Natchayaporn,Upanan Pornpailin,Adulyaritthikul Punyanuch,Krungchanuchat Saowalak,Panupinthu Nattapon,Teerapornpuntakit Jarinthorn,Rojviriya Catleya,Lertsuwan Kornkamon,Svasti Saovaros,Wongdee Kannikar
Abstract
AbstractThalassemia causes anemia, ineffective erythropoiesis, bone loss and iron accumulation in several tissues, e.g., liver, bone and heart, the last of which leads to lethal cardiomyopathy and arrhythmia. Although exercise reportedly improves bone density in thalassemic mice, exercise performance is compromised and might pose risk of cardiovascular accident in thalassemic patients. Therefore, we sought to explore whether mild-intensity physical activity (MPA) with 30–50% of maximal oxygen consumption was sufficient to benefit the heart and bone. Herein, male hemizygous β-globin knockout (BKO) mice and wild-type littermates were subjected to voluntary wheel running 1 h/day, 5 days/week for 3 months (MPA group) or kept sedentary (SDN; control). As determined by atomic absorption spectroscopy, BKO-MPA mice had less iron accumulation in heart and bone tissues compared with BKO-SDN mice. Meanwhile, the circulating level of fibroblast growth factor-23—a factor known to reduce serum iron and intestinal calcium absorption—was increased early in young BKO-MPA mice. Nevertheless, MPA did not affect duodenal calcium transport or body calcium retention. Although MPA restored the aberrant bone calcium-phosphorus ratio to normal range, it did not change vertebral calcium content or femoral mechanical properties. Microstructural porosity in tibia of BKO-MPA mice remained unaltered as determined by synchrotron radiation X-ray tomographic microscopy. In conclusion, MPA prevents cardiac and bone iron accumulation, which is beneficial to thalassemic patients with limited physical fitness or deteriorated cardiac performance. However, in contrast to moderate-intensity exercise, MPA does not improve bone mechanical properties or reduce bone porosity.
Funder
Mahidol University–Multidisciplinary Research Cluster Grant
National Research Council of Thailand–Mahidol University Grant
Thailand Research Fund (TRF) through the International Research Network Program
Faculty of Science, Mahidol University
Science Achievement Scholarship of Thailand (SAST) and the King Prajadhipok and Queen Rambhai Barni Memorial Foundation
TRF/NRCT-Royal Golden Jubilee Ph.D. Program
Postdoctoral Research Fellowships, Mahidol University
TRF–Office of the Higher Education Commission Research Grant for New Scholar
Burapha University
Publisher
Springer Science and Business Media LLC
Cited by
1 articles.
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