Chronic brain inflammation and persistent herpes simplex virus 1 thymidine kinase expression in survivors of syngeneic glioma treated by adenovirus-mediated gene therapy: Implications for clinical trials

Author:

Dewey R. A.,Morrissey G.,Cowsill C. M.,Stone D.,Bolognani F.,Dodd N.J.F.,Southgate T. D.,Klatzmann D.,Lassmann H.,Castro M.G.,Löwenstein P.R.

Publisher

Springer Science and Business Media LLC

Subject

General Biochemistry, Genetics and Molecular Biology,General Medicine

Reference45 articles.

1. Izquierdo, M. et al. Human malignant brain tumour response to herpes simplex tymidine kinase (HSVtk)/ganciclovir gene therapy. Gene Therapy 3, 491–495 (1996).

2. Ram, Z. et al. Therapy of malignant brain tumors by intratumoral implantation of retroviral vector-producing cells. Nature Medicine 3, 1354–1361 (1997).

3. Klatzmann, D. et al. A phase I/II study of herpes simplex virus type 1 thymidine kinase "suicide" gene therapy for recurrent glioblastoma. Hum. Gene Ther. 9, 2595–2604 (1998).

4. Eck, S.L. et al. Treatment of advanced CNS malignancies with the recombinant adenovirus H5.010RSVTK: a phase I trial. Hum. Gene Ther. 7, 1465–1482 (1996).

5. Freeman, S. et al. The "bystander effect": tumour regression when a fraction of the tumour mass is genetically modified. Cancer Res. 53, 5274–5283 (1993).

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